56 -3 (89) 2026 - Kurbanova Z.Ch., Kho‘shboqova G.O. - CLINICAL SIGNIFICANCE OF LIVER-9 LINE ANTIGENS TESTING AND INDICATORS FOR PREDICTING LIVER DAMAGE IN PATIENTS WITH AUTOIMMUNE HEMOLYTIC ANEMIA

CLINICAL SIGNIFICANCE OF LIVER-9 LINE ANTIGENS TESTING AND INDICATORS FOR PREDICTING LIVER DAMAGE IN PATIENTS WITH AUTOIMMUNE HEMOLYTIC ANEMIA

Kurbanova Z.Ch. - Tashkent State Medical University

Kho‘shboqova G.O. - Tashkent State Medical University

Resume

Autoimmune hemolytic anemia (AIHA) is an acquired hemolytic disease caused by autoimmune antibodies, the clinical course of which is diverse and variable. It manifests itself in various degrees, from mild and compensated hemolysis to severe clinical forms that pose a serious threat to life. AIGA is a relatively rare disease, and its prevalence is on average 1–3 cases per 100,000 population per year. The disease is manifested mainly by the rapid destruction of red blood cells due to the pathogenetic effect of autoantibodies. This process occurs mainly extravascularly, mainly in the spleen and liver, and in rare cases, it is observed in the form of intravascular hemolysis.

Keywords: AIGA, AIG, Blot strip, diluent, conjugate, washing solution, substrate, TRAY, SHEET, strip.

First page

350

Last page

352

For citation:Kurbanova Z.Ch., Kho‘shboqova G.O. - CLINICAL SIGNIFICANCE OF LIVER-9 LINE ANTIGENS TESTING AND INDICATORS FOR PREDICTING LIVER DAMAGE IN PATIENTS WITH AUTOIMMUNE HEMOLYTIC ANEMIA//New Day in Medicine 3(89)2026 350-352 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

List of References

1. Barcellini W, Fattizzo B. Clinical applications of hemolytic markers in the differential diagnosis and management of hemolytic anemia. Dis Markers. 2015;2015:635670. doi:10.1155/2015/635670.
2. Fava A, Petri M. Systemic lupus erythematosus: Diagnosis and clinical management. J Autoimmun. 2019;96:1–13. doi:10.1016/j.jaut.2018.11.001.
3. Michalak SS, Olewicz-Gawlik A, Rupa-Matysek J, Wolny-Rokicka E, Nowakowska E, Gil L. Autoimmune hemolytic anemia: current knowledge and perspectives. Immun Ageing. 2020;17:38. doi:10.1186/s12979-020-00192-2.
4. Barcellini W, Giannotta J, Fattizzo B. Autoimmune hemolytic anemia in adults: primary risk factors and diagnostic procedures. Expert Rev Hematol. 2020;13(6):585–597. doi:10.1080/17474086.2020.1763409.
5. Alimov AN, et al. Changes in immune parameters in patients with chronic glomerulonephritis. Bulletin of the Tashkent Medical Academy. 2023;(2):44–49.
6. Ministry of Health of Uzbekistan. Clinical protocols for the diagnosis and treatment of kidney diseases. Tashkent; 2024.

   file

   download