16 -4 (90) 2026 - Kakhkharov A.S., Ibragimov Kh.I. - IMMUNOLOGICAL FEATURE OF AVASCULAR NECROSIS OF THE FEMORAL HEAD IN RHEUMATOLOGY

IMMUNOLOGICAL FEATURE OF AVASCULAR NECROSIS OF THE FEMORAL HEAD IN RHEUMATOLOGY

Kakhkharov A.S. - Samarkand State Medical University

Ibragimov Kh.I. - Samarkand State Medical University

Resume

Clinical, immunological, and metabolic alterations observed in patients with avascular necrosis of the femoral head in the context of rheumatologic diseases reflect the multifactorial nature of its pathogenesis. A high prevalence of concomitant cardiovascular pathology and lipid metabolism disorders has been identified, indicating a significant role of vascular factors in disease development. Elevated levels of proinflammatory cytokines, including tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta, confirm the involvement of immune-inflammatory mechanisms in disease progression. At the same time, baseline immunological parameters remain largely unchanged, suggesting the predominance of functional rather than quantitative immune disturbances. In addition, signs of hypercoagulability, including increased levels of D-dimer and fibrinogen, as well as dyslipidemia, are associated with impaired microcirculation and the development of bone ischemia. Thus, avascular necrosis of the femoral head should be considered a systemic condition resulting from the interaction of vascular, immunological, and metabolic factors.

Key words: Avascular necrosis, rheumatology, cytokines, hypercoagulability, dyslipidemia

First page

78

Last page

82

For citation:Kakhkharov A.S., Ibragimov Kh.I., Ziyadullaev Sh.Kh. - IMMUNOLOGICAL FEATURE OF AVASCULAR NECROSIS OF THE FEMORAL HEAD IN RHEUMATOLOGY//New Day in Medicine 4(90)2026 78-82 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

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