30 -4 (90) 2026 - Akhmedov F.K. Muminova N.Kh. - FEATURES OF THE CYTOKINE SYSTEM IN WOMEN OF REPRODUCTIVE AGE WITH THE COMBINATION OF ENDOMETRIOSIS, ADENOMYOSIS, AND UTERINE FIBROIDS

FEATURES OF THE CYTOKINE SYSTEM IN WOMEN OF REPRODUCTIVE AGE WITH THE COMBINATION OF ENDOMETRIOSIS, ADENOMYOSIS, AND UTERINE FIBROIDS

Akhmedov F.K. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Muminova N.Kh. - Center for Professional Development of Medical Personnel Uzbekistan

Djumayeva S.T. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This study examined the immunological characteristics of inflammatory processes in women complicated by endometriosis, adenomyosis, and uterine fibroids. Based on the results, it was established that the levels of pro-inflammatory cytokines—IL-1β, IL-6, and TNF-α—were significantly higher in such patients than in the control group. Especially in cases where uterine fibroids joined endometriosis, these indicators increased even further, indicating an increase in the activity of the inflammatory process. At the same time, the cytokines IL-1β, IL-6 and TNF-α are of diagnostic importance, and their sensitivity and specificity indicators confirmed the possibility of their use as reliable biomarkers in the detection of endometriosis and associated pathologies. At the same time, the cytokines IL-1β, IL-6 and TNF-α are of diagnostic importance, and their sensitivity and specificity indicators confirmed the possibility of their use as reliable biomarkers in the detection of endometriosis and associated pathologies. In particular, it was noted that IL-1β possesses the highest diagnostic efficacy. The results obtained show that immune system imbalance and inflammatory processes play an important role in the development of endometriosis and comorbidities, and cytokine indicators are of great importance in early diagnosis and disease prognosis.

Keywords: endometriosis, cytokines, IL-1β, IL-6, TNF-α, uterine fibroids.

First page

207

Last page

212

For citation:Akhmedov F.K. Muminova N.Kh., Djumayeva S.T. - FEATURES OF THE CYTOKINE SYSTEM IN WOMEN OF REPRODUCTIVE AGE WITH THE COMBINATION OF ENDOMETRIOSIS, ADENOMYOSIS, AND UTERINE FIBROIDS//New Day in Medicine 4(90)2026 207-212 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

List of References

1. Беширова Э.Т., Конак М.А. Современные взгляды на этиопатогенез эндометриоза: клиническая демонстрация проблемных вопросов. Молодежный инновационный вестник. 2025;14(1):6-9.
2. Бурлев В.А., Шорохова М.А., Самойлова Т.Е. Современные принципы патогенетического лечения эндометриоза. Consilium Medicum. 2007;9(6):8-12.
3. Девятова Е.А., Цатурова К.А., Эсмурзиева З.И., Вартанян Э.В. Эндометриоз. Акушерство и гинекология: Новости. Мнения. Обучения. 2015;(3):54-58.
4. Доброхотова Ю.Э., Маркова Э.А., Хлынова С.А., Нариманова М.Р. Эндометриоз. Обзор клинического протокола под разным углом зрения (дискуссия). РМЖ. Мать и дитя. 2024;7(2):89-97.
5. Зиганшин А.М., Мулюков А.Р., Мудров В.А. Генитальный эндометриоз и фертильность. Российский вестник акушера-гинеколога. 2022;22(5):37-42.
6. Bonavina G, Taylor HS. Endometriosis-associated infertility: From pathophysiology to tailored treatment. Front Endocrinol (Lausanne). 2022;13:1020827. doi:10.3389/fendo.2022.1020827.
7. Dai Y, Ye Z, Lin X, Zhang S. Immunopathological insights into endometriosis: from research advances to future treatments. Semin Immunopathol. 2025;47(1):31-39. doi:10.1007/s00281-025-009xx-x. (уточнить DOI при необходимости)
8. Qiu XM, Lai ZZ, Ha SY, Yang HL, Liu LB, Wang Y, Shi JW, Ruan LY, Ye JF, Wu JN, Fu Q, Yi XF, Chang KK, Li MQ. IL-2 and IL-27 synergistically promote growth and invasion of endometriotic stromal cells by maintaining the balance of IFN-γ and IL-10 in endometriosis. Reproduction. 2020;159(3):251-260. doi:10.1530/REP-19-0407.

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