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  • 46 -4 (90) 2026 - Orifkhojaeva M.V., Norova M.B. - CHRONIC LEUKEMIA AND PERIODONTITIS: EFFICACY OF IMMUNOLOGICAL REHABILITATION USING INTRAVENOUS LASER BLOOD IRRADIATION (ILBI)

46 -4 (90) 2026 - Orifkhojaeva M.V., Norova M.B. - CHRONIC LEUKEMIA AND PERIODONTITIS: EFFICACY OF IMMUNOLOGICAL REHABILITATION USING INTRAVENOUS LASER BLOOD IRRADIATION (ILBI)

CHRONIC LEUKEMIA AND PERIODONTITIS: EFFICACY OF IMMUNOLOGICAL REHABILITATION USING INTRAVENOUS LASER BLOOD IRRADIATION (ILBI)

Orifkhojaeva M.V. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Norova M.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This study presents a comprehensive analysis of oral mucosal disease manifestations in patients with chronic leukemia, integrating clinical, immunological, and microbiological parameters. For the first time, a correlation between humoral immunity changes (IgA, IgG, IgM, and CIC levels) and the severity of oral inflammatory processes was scientifically established. Microbiological analysis revealed a predominance of Gram-negative anaerobes, with their concentration and strain dynamics being closely linked to the stages of chronic leukemia. The study validates the pathogenetic efficacy of Intravenous Laser Blood Irradiation (ILBI) in complex treatment and introduces personalized therapeutic and preventive recommendations for dental complications.

Keywords: chronic leukemia, periodontitis, oral mucosa, humoral immunity, microflora, ILBI, pathogenesis.

First page

332

Last page

336

For citation:Orifkhojaeva M.V., Norova M.B. - CHRONIC LEUKEMIA AND PERIODONTITIS: EFFICACY OF IMMUNOLOGICAL REHABILITATION USING INTRAVENOUS LASER BLOOD IRRADIATION (ILBI)//New Day in Medicine 4(90)2026 332-336 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

List of References

  1. Al-Azri AR, Al-Rawas AS, Al-Kindi SS. Oral manifestations of hematological malignancies: A diagnostic and management challenge. J Cancer Res Ther. 2021;17(2):295–302. doi:10.4103/jcrt.JCRT_911_20
  2. Botushanov PI, Marinova MS. Microbiological and immunological aspects of periodontitis in patients with chronic leukemia. Int J Stomatol Occlusion Med. 2019;12(1):15–21.
  3. Gomes AC, Silva BT. Efficacy of low-level laser therapy (LLLT) in the treatment of chemotherapy-induced oral mucositis: A systematic review. Lasers Med Sci. 2022;37(4):2105–2118. doi:10.1007/s10103-022-03512-y
  4. Kamilov KP, Ibragimova MK. Modern methods of treating periodontal diseases in patients with systemic diseases. Cent Asian J Med. 2020;(3):45–56.
  5. Nazarova MB. Clinical and immunological evaluation of oral health in patients with hemoblastosis [dissertation]. Bukhara: Bukhara State Medical Institute; 2023.
  6. Schmalz G, Ziebolz D. The interface between dentistry and hematology: A clinical update. Clin Oral Investig. 2020;24(9):2957–2969. doi:10.1007/s00784-020-03445-5
  7. Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000. 2005;38(1):135–187.
  8. Zaynutdinov SS, Rasulova NA. Intravenous laser blood irradiation (ILBI) in the complex treatment of inflammatory oral diseases. Uzbekistan Med J. 2024;65(1):112–119.
  9. Норова МБ, Орифхўжаева МВ. Сравнительная оценка состояния слизистой оболочки полости рта и тканей пародонта у больных хроническим лейкозом. Вестник фундаментальной и клинической медицины. 2026;2(22):539–543. Available from: https://vestnik-fkm.uz/issue/view/2026-2-22-norova
  10. Норова МБ, Орифхўжаева МВ. Сурункали оққон билан касалланган беморларда оғиз бўшлиғи шиллиқ қавати касалликларини даволашга замонавий ёндашувлар. Тиббиётда янги кун. 2026;4(56):245–250. Available from: https://newdayworldmedicine.com/en/article/7308

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