50 -4 (90) 2026 - Madaminov F. - MODELING OF CLINICAL-PROGNOSTIC FACTORS IN ADRENAL TUMORS IN THE ARAL REGION

MODELING OF CLINICAL-PROGNOSTIC FACTORS IN ADRENAL TUMORS IN THE ARAL REGION

Madaminov F. - Khorezm Branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Resume

To comprehensively evaluate clinical, morphological and immunohistochemical factors of adrenal tumors in the Aral Sea region and to develop an integrated prognostic model for assessing the risk of disease progression and metastasis. Materials and Methods: The study included 186 patients examined between 2016 and 2024 using both retrospective and prospective approaches. Clinical (age, sex, symptoms), morphological (tumor type, differentiation grade), immunohistochemical (Ki-67, Melan A, S-100) and functional (hormonal activity) parameters were analyzed. Statistical methods included Pearson correlation, multivariate logistic regression, and Kaplan–Meier survival analysis. Statistical significance was set at p<0.05. Results: Ki-67 index (r=0.68; p<0.01), tumor size (r=0.54; p<0.05), and hormonal activity (r=0.49; p<0.05) were identified as the most significant prognostic factors. Patients with Ki-67 >20% demonstrated a complication rate of 58%, which was 2.1 times higher than in the low-risk group. Metastasis incidence was also 1.8 times higher. An integrated risk index (IRI) was developed, stratifying patients into low-, intermediate-, and high-risk groups. Disease progression in the high-risk group was observed 2.3 times more frequently. Kaplan–Meier analysis showed a 5-year survival rate of 75% in the low-risk group compared to 30% in the high-risk group (p<0.01). ROC analysis demonstrated an AUC of 0.82, indicating high predictive accuracy of the model. Conclusion: The integrated model combining clinical, morphological and immunohistochemical parameters provides a reliable tool for predicting disease course, assessing metastatic risk, and optimizing individualized treatment strategies.

Keywords: adrenal gland, Ki-67, prognosis, metastasis, risk model, immunohistochemistry.

First page

357

Last page

363

For citation:Madaminov F. - MODELING OF CLINICAL-PROGNOSTIC FACTORS IN ADRENAL TUMORS IN THE ARAL REGION//New Day in Medicine 4(90)2026 357-363 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

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