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  • 53 -4 (90) 2026 - Hasanova M.A., To’qsanova D.I. - THE ROLE OF VAGINAL MICROBIOCENOSY IN THE PATHOGENESIS OF ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE

53 -4 (90) 2026 - Hasanova M.A., To’qsanova D.I. - THE ROLE OF VAGINAL MICROBIOCENOSY IN THE PATHOGENESIS OF ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE

THE ROLE OF VAGINAL MICROBIOCENOSY IN THE PATHOGENESIS OF ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE

Hasanova M.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

To’qsanova D.I. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This article analyzes the role of vaginal microbiocenosis in the pathogenesis of endometrial hypertrophy (EG) in women of reproductive age, as well as the mechanisms of disease development, clinical features and morphofunctional changes. Hyperestrogenemia, hormonal imbalance, disruption of proliferation and apoptosis processes, oxidative stress and changes in receptor systems were considered as the main pathogenetic factors of endometrial hypertrophy. Proliferative activity and cell cycle disorders in endometrial tissue were assessed based on immunohistochemical markers (Ki-67, ER, PR, MMP-9, cyclin D1).

Keywords: endometrial hypertrophy, vaginal microbiocenosis, hyperestrogenemia, Ki-67, estrogen receptors, progesterone receptors, oxidative stress, immunohistochemistry, apoptosis, proliferation, cytokines, microbiota

First page

376

Last page

382

For citation:Hasanova M.A., To’qsanova D.I. - THE ROLE OF VAGINAL MICROBIOCENOSY IN THE PATHOGENESIS OF ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE//New Day in Medicine 4(90)2026 376-382 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

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