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  • 60 -4 (90) 2026 - Agababyan L.R., Alimjanovich R.J. - ULTRASOUND AND DOPPLER MARKERS OF FETOPLACENTAL INSUFFICIENCY AND MACROSOMIA IN PREGNANT WOMEN WITH GESTATIONAL DIABETES: A RETROSPECTIVE COHORT STUDY

60 -4 (90) 2026 - Agababyan L.R., Alimjanovich R.J. - ULTRASOUND AND DOPPLER MARKERS OF FETOPLACENTAL INSUFFICIENCY AND MACROSOMIA IN PREGNANT WOMEN WITH GESTATIONAL DIABETES: A RETROSPECTIVE COHORT STUDY

ULTRASOUND AND DOPPLER MARKERS OF FETOPLACENTAL INSUFFICIENCY AND MACROSOMIA IN PREGNANT WOMEN WITH GESTATIONAL DIABETES: A RETROSPECTIVE COHORT STUDY

Agababyan L.R. - Samarkand State Medical University

Alimjanovich R.J. - Samarkand State Medical University

Yeszhanova A.A. - Samarkand State Medical University

Resume

Objective: To evaluate ultrasound and Doppler markers in pregnant women with gestational diabetes (GDM) depending on insulin therapy. Materials and Methods: A retrospective cohort study was conducted on 600 pregnant women: 300 with GDM and 300 with physiological pregnancy. The GDM group was divided into diet therapy (n=180) and insulin therapy (n=120). Polyhydramnios, uteroplacental blood flow (UPBF) disorders, macrosomia, diabetic fetopathy, and neonatal transfers to the intensive care unit (NICU) were assessed. Statistics: Mann–Whitney U test, Pearson χ², Fisher’s exact test. Results: GDM was associated with increased incidence of polyhydramnios (7.0% vs 1.3% in controls; p=0.0013) and UPBF disorders (27.7% vs 20.7%; p=0.045). The mean gestational age at insulin therapy initiation was 32.27 ± 2.67 weeks. Delayed initiation of insulin therapy increased the incidence of diabetic fetopathy (8.3% vs 2.2% in diet therapy, p=0.0136) and NICU transfers (12.5% vs 5.6%, p=0.028), with no significant differences in macrosomia (14.2% vs 13.9%, p=0.877). Conclusion: Early ultrasound and Doppler changes occur before macrosomia; markers of fetopathy and polyhydramnios require immediate insulin therapy.

Keywords: Gestational diabetes, diabetic fetopathy, macrosomia, polyhydramnios, insulin therapy.

First page

421

Last page

427

For citation:Agababyan L.R., Alimjanovich R.J., Yeszhanova A.A. - ULTRASOUND AND DOPPLER MARKERS OF FETOPLACENTAL INSUFFICIENCY AND MACROSOMIA IN PREGNANT WOMEN WITH GESTATIONAL DIABETES: A RETROSPECTIVE COHORT STUDY//New Day in Medicine 4(90)2026 332-336 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

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