65 -4 (90) 2026 - Sanoev B.A., Khahramonova Sh. - MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF OVARIAN ENDOMETRIOSIS IN PATIENTS AGED 18–25 YEARS

MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF OVARIAN ENDOMETRIOSIS IN PATIENTS AGED 18–25 YEARS

Sanoev B.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Khahramonova Sh. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Ovarian endometrioma is one of the most common forms of genital endometriosis and is characterized by pronounced morphological and stromal-vascular changes affecting the functional state of the organ. This study analyzes the morphological and immunohistochemical features of ovarian tissue in patients aged 18–22 years. The material consisted of surgical ovarian tissue samples obtained after removal from patients with endometrioma. Morphological examination was performed using Van Gieson staining, while immunohistochemical analysis was carried out using desmin and vimentin markers with DAB chromogen visualization. It was established that endometrioma is characterized by the presence of cystic endometrioid glands, pronounced sclerotic changes in the stroma, disorganization of collagen fibers, thickening of vascular walls, and narrowing of their lumen. Immunohistochemical analysis revealed increased vimentin expression, as well as the presence of desmin-positive cells in the vascular wall and stroma, reflecting activation of stromal elements and tissue remodeling processes. These findings indicate the development of a chronic inflammatory process, fibrosis, and disruption of the structural organization of ovarian tissue in endometriosis.

Keywords: ovarian endometrioma, ovarian endometriosis, morphology, immunohistochemistry, desmin, vimentin, stroma, fibrosis, vascular changes

First page

447

Last page

451

For citation:Sanoev B.A., Khahramonova Sh. - MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF OVARIAN ENDOMETRIOSIS IN PATIENTS AGED 18–25 YEARS//New Day in Medicine 4(90)2026 447-451 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

List of References

1. Taylor HS, Kotlyar AM, Flores VA. Эндометриоз является хроническим системным заболеванием: клинические проблемы и новые инновации. The Lancet. 2021;397(10276):839–851. doi:10.1016/S0140-6736(21)00389-5
2. Chapron C, Marcellin L, Borghese B, Santulli P. Переосмысление механизмов, диагностики и лечения эндометриоза. Nature Reviews Endocrinology. 2019;15(11):666–682. doi:10.1038/s41574-019-0245-z
3. Abreu AP, Kaiser UB. Половое созревание и его регуляция. The Lancet Diabetes & Endocrinology. 2016;4(3):254–264. doi:10.1016/S2213-8587(15)00418-0
4. Yunker A. Сочетание хронических болевых расстройств у подростков указывает на раннее формирование болевой программы и возможное оптимальное время для вмешательства. Fertility and Sterility. 2018;109(4):617–618. doi:10.1016/j.fertnstert.2018.01.026
5. Chapron C, Lafay-Pillet MC, Monceau E, и др. Опрос пациентов об их подростковом периоде может помочь выявить маркеры, связанные с глубоко инфильтрирующим эндометриозом. Fertility and Sterility. 2011;95(3):877–881. doi:10.1016/j.fertnstert.2010.10.027

   file

   download