68 -4 (90) 2026 - Razzakov O.G., Saidov M.A. - CLINICAL-PATHOGENETIC PHENOTYPES AND PERSONALIZED MEDICAL REHABILITATION AFTER TOTAL KNEE JOINT ENDOPROSTHESIS IN PRIMARY GONARTHROSIS: A REVIEW OF MODERN LITERATURE

CLINICAL-PATHOGENETIC PHENOTYPES AND PERSONALIZED MEDICAL REHABILITATION AFTER TOTAL KNEE JOINT ENDOPROSTHESIS IN PRIMARY GONARTHROSIS: A REVIEW OF MODERN LITERATURE

Razzakov O.G. - National Medical Center, Tashkent

Saidov M.A. - National Medical Center, Tashkent

Sabirov D.R. - National Medical Center, Tashkent

Resume

The aim of this review was to analyze post-total knee arthroplasty heterogeneity in primary gonarthrosis and to summarize the evidence supporting phenotype-oriented personalized medical rehabilitation. A narrative review of PubMed, Scopus, and Web of Science publications from 2020 to 2025 was performed, prioritizing clinical practice guidelines, systematic reviews, meta-analyses, randomized trials, and cohort studies. Current evidence shows that clinically relevant pain and functional limitations persist in a substantial proportion of patients after technically successful total knee arthroplasty. The most important unfavorable trajectories are associated with inflammatory-edematous, neuromuscular inhibition, sensitization/noceplastic, and sarcopenic-metabolic phenotypes. Early stratification based on pain intensity, joint-specific and performance-based outcomes, quadriceps strength, Central Sensitization Inventory, PainDETECT, musculoskeletal ultrasound, and inflammatory biomarkers may help tailor rehabilitation modules to the dominant pathophysiological mechanism. Phenotype-oriented rehabilitation should therefore be viewed not as an optional add-on but as a core principle of modern postoperative rehabilitation after total knee arthroplasty.

Keywords: primary gonarthrosis, total knee arthroplasty, persistent postoperative pain, clinical phenotype, personalized rehabilitation, central sensitization.

First page

464

Last page

469

For citation:Razzakov O.G., Saidov M.A., Sabirov D.R. - CLINICAL-PATHOGENETIC PHENOTYPES AND PERSONALIZED MEDICAL REHABILITATION AFTER TOTAL KNEE JOINT ENDOPROSTHESIS IN PRIMARY GONARTHROSIS: A REVIEW OF MODERN LITERATURE//New Day in Medicine 4(90)2026 464-469 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

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