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  • 75 -4 (90) 2026 - Urunbayeva M.N., Ibragimov Kh.I. - CLINICAL, HORMONAL, AND IMMUNOGENETIC FEATURES OF DIFFERENT PHENOTYPES OF AUTOIMMUNE THYROIDITIS CONSIDERING ESR1 GENE POLYMORPHISM

75 -4 (90) 2026 - Urunbayeva M.N., Ibragimov Kh.I. - CLINICAL, HORMONAL, AND IMMUNOGENETIC FEATURES OF DIFFERENT PHENOTYPES OF AUTOIMMUNE THYROIDITIS CONSIDERING ESR1 GENE POLYMORPHISM

CLINICAL, HORMONAL, AND IMMUNOGENETIC FEATURES OF DIFFERENT PHENOTYPES OF AUTOIMMUNE THYROIDITIS CONSIDERING ESR1 GENE POLYMORPHISM

Urunbayeva M.N. - Samarkand State Medical University

Ibragimov Kh.I. - Samarkand State Medical University

Ziyadullayev Sh.Kh. - Tashkent International University of Chemistry Uzbekistan

Resume

The aim of the study was to evaluate the clinical, metabolic, hormonal, and immunological characteristics of different phenotypes of autoimmune thyroiditis (AIT). A prospective observational study was conducted between 2023 and 2025, including 122 patients with confirmed AIT, divided into three groups: hypothyroid (n=43), euthyroid (n=66), and thyrotoxic (n=13). The control group consisted of 100 apparently healthy individuals. The results showed that patients with hypothyroid AIT had a higher body mass index (28.6±4.9 kg/m²), increased prevalence of arterial hypertension (41.9%), type 2 diabetes mellitus (20.9%), and dyslipidemia (48.8%), as well as a longer disease duration. The thyrotoxic form was associated with pronounced hormonal changes, including elevated free T3 and T4 levels, presence of TSH receptor antibodies (69.2%), and increased thyroid vascularization. Analysis of the estrogen axis revealed decreased estradiol levels and free estradiol index in hypothyroid patients, while these parameters were increased in thyrotoxic patients. ESR1 gene polymorphism was significantly associated with sex hormone-binding globulin levels (p=0.003) and free estradiol index (p<0.001), but not with total estradiol levels (p=0.421), indicating its role in regulating hormone bioavailability.

Keywords: Autoimmune thyroiditis; ESR1 polymorphism; estrogen axis; thyroid hormones; immunogenetics

First page

510

Last page

504

For citation:Urunbayeva M.N., Ibragimov Kh.I., Ziyadullayev Sh.Kh. - CLINICAL, HORMONAL, AND IMMUNOGENETIC FEATURES OF DIFFERENT PHENOTYPES OF AUTOIMMUNE THYROIDITIS CONSIDERING ESR1 GENE POLYMORPHISM//New Day in Medicine 4(90)2026 504-510 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

List of References

  1. Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P. Autoimmune thyroid disorders. Autoimmunity Reviews. 2015;14(2):174–180. doi:10.1016/j.autrev.2014.10.016
  2. Brown RS. Autoimmune thyroiditis in childhood. Journal of Clinical Research in Pediatric Endocrinology. 2013;5(Suppl 1):45–49.
  3. Chen Y, Chen Y, Xia F, Wang N, Chen C, Nie X, et al. A higher ratio of estradiol to testosterone is associated with autoimmune thyroid disease in males. Thyroid. 2017;27(7):960–966. doi:10.1089/thy.2016.0661
  4. Doukas C, Saltiki K, Mantzou A, Cimponeriu A, Terzidis K, Sarika L, et al. Hormonal parameters and sex hormone receptor gene polymorphisms in men with autoimmune diseases. Rheumatology International. 2013;33(3):575–582. doi:10.1007/s00296-012-2386-4
  5. Dragin N, Bismuth J, Cizeron-Clairac G, Biferi MG, Berthault C, Serraf A, et al. Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases. Journal of Clinical Investigation. 2016;126(4):1525–1537. doi:10.1172/JCI81894
  6. Drehmer MN, Andrade D, Pereira IA, Marrero AR, Muniz YCN, De Souza IR, et al. Estrogen receptor alpha gene (ESR1) polymorphism can contribute to clinical findings in systemic lupus erythematosus patients. Lupus. 2017;26(3):294–298. doi:10.1177/0961203316668041
  7. Durá-Travé T, Gallinas-Victoriano F. Autoimmune thyroiditis and vitamin D. International Journal of Molecular Sciences. 2024;25(6):3154. doi:10.3390/ijms25063154
  8. Fallahi P, Ferrari SM, Ruffilli I, Elia G, Biricotti M, Vita R, et al. The association of other autoimmune diseases in patients with autoimmune thyroiditis: review of the literature and report of a large series of patients. Autoimmunity Reviews. 2016;15(12):1125–1128. doi:10.1016/j.autrev.2016.09.009
  9. FitzPatrick AM. Is estrogen a missing culprit in thyroid eye disease? Sex steroid hormone homeostasis is key to other fibrogenic autoimmune diseases—why not this one? Frontiers in Immunology. 2022;13:898138. doi:10.3389/fimmu.2022.898138
  10. Iddah MA, Macharia BN. Autoimmune thyroid disorders. ISRN Endocrinology. 2013;2013:509764. doi:10.1155/2013/509764

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