9 -5 (91) 2026 - D.M. Khakimov, G.M. Khodzhimatov - PERSONALIZED STRATEGY FOR THE PROGNOSTICATION AND PREVENTION OF RECURRENT ULCERATIVE AND EROSIVE GASTRODUODENAL BLEEDING IN COMORBID PATIENTS: THE ROLE OF ENDOTHELIAL DYSFUNCTION

PERSONALIZED STRATEGY FOR THE PROGNOSTICATION AND PREVENTION OF RECURRENT ULCERATIVE AND EROSIVE GASTRODUODENAL BLEEDING IN COMORBID PATIENTS: THE ROLE OF ENDOTHELIAL DYSFUNCTION

D.M. Khakimov - Andijan State Medical Institute

G.M. Khodzhimatov - Andijan State Medical Institute

B.B. Karaboev - Andijan State Medical Institute

Kh.Kh. Khamdamov - Andijan State Medical Institute

Resume

The recurrence of ulcerative and erosive gastroduodenal bleeding in patients with a pronounced comorbid background remains a major challenge in emergency surgery. Traditional prognostic systems do not fully reflect hidden pathogenetic disorders, particularly systemic and local endothelial dysfunction. A comprehensive analysis of the treatment outcomes of 338 patients with non-variceal bleeding revealed a high level of polymorbidity (mean Charlson index of 4.8±1.8 points) and a predominance of diffuse erosive mucosal lesions covering multiple anatomical zones. The implementation of a risk-oriented prognostic system integrating clinical and endoscopic parameters with markers of endothelial activity (endothelin-1, nitric oxide, VEGF) allows for the objective identification of high-risk groups. This approach provides a differentiated selection of endoscopic hemostasis tactics and early endovascular interventions, contributing to the effective personalized prevention of recurrent hemorrhages in comorbid patients.

Keywords: gastroduodenal bleeding, comorbidity, Charlson index, endothelial dysfunction, endoscopic hemostasis, risk-oriented approach, recurrent hemorrhage.

First page

51

Last page

57

For citation:D.M. Khakimov, G.M. Khodzhimatov, B.B. Karaboev, Kh.Kh. Khamdamov - PERSONALIZED STRATEGY FOR THE PROGNOSTICATION AND PREVENTION OF RECURRENT ULCERATIVE AND EROSIVE GASTRODUODENAL BLEEDING IN COMORBID PATIENTS: THE ROLE OF ENDOTHELIAL DYSFUNCTION//New Day in Medicine 5(91)2026 51-57 https://newdayworldmedicine.com/en/new_day_medicine/5-91-2026

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