80 -5 (91) 2026 - G.A. Primova - MORPHOFUNCFTIONAL FEATURES OF POPLITEAL LYMPH NODES IN EXPERIMENTAL DIABETES MELLITUS

MORPHOFUNCFTIONAL FEATURES OF POPLITEAL LYMPH NODES IN EXPERIMENTAL DIABETES MELLITUS

G.A. Primova - Tashkent State Medical University

Resume

Diabetes mellitus is a chronic metabolic disease characterized by profound disturbances in carbohydrate, lipid, and protein metabolism, leading to structural and functional alterations in various organs and systems of the body. Particular attention has recently been focused on diabetes-induced changes in immune system organs, including peripheral lymphoid structures. Popliteal lymph nodes play a crucial role in the development of immune responses and maintenance of immune homeostasis. Under conditions of experimental diabetes mellitus, lymph nodes undergo a series of morphological and functional changes, including remodeling of lymphoid tissue, microcirculatory disturbances, decreased proliferative activity of immunocompetent cells, and increased apoptosis.This review article analyzes current scientific literature concerning the morphofunctional changes occurring in popliteal lymph nodes under experimental diabetes mellitus. Available evidence indicates that hyperglycemia and diabetic microangiopathy contribute to the reduction of lymphoid follicle size, narrowing of the paracortical zone, enhancement of fibrotic processes, and suppression of immune reactivity within lymph nodes. These findings demonstrate the significant impact of diabetes mellitus on the structural organization and functional status of peripheral immune organs.

Keywords: diabetes mellitus, experimental diabetes, popliteal lymph node, morphometry, lymphoid tissue, immunity, microcirculation, histology, immunohistochemistry.

First page

472

Last page

475

For citation:G.A. Primova - MORPHOFUNCFTIONAL FEATURES OF POPLITEAL LYMPH NODES IN EXPERIMENTAL DIABETES MELLITUS//New Day in Medicine 5(91)2026 472-475 https://newdayworldmedicine.com/en/new_day_medicine/5-91-2026

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