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1 -6 (92) 2026 - Sarkisova L.V., Sharopova M.M. - PROGNOSTIC VALUE OF IMMUNOLOGICAL MARKERS IN IMPROVING PRETERM BIRTH OUTCOMES

PROGNOSTIC VALUE OF IMMUNOLOGICAL MARKERS IN IMPROVING PRETERM BIRTH OUTCOMES

Sarkisova L.V. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Sharopova M.M. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The article presents the results of a study of cytokines and their role during pregnancy. The content of cytokines in blood serum reflects the state of cytokine balance; therefore, determination of their levels has high informative value for judging the course of pregnancy and intrauterine development of the fetus. The balance between pro-inflammatory and anti-inflammatory cytokines is critical for fetal implantation, placental preparation and pregnancy outcome, and increased production of pro-inflammatory cytokines in the early stages of pregnancy leads to preterm birth. The course of pregnancy and childbirth was studied in 200 women at a gestational age of 22-36 weeks. Patients of the main group (n=150) were divided into two groups: group 1 (n=65) included patients with threatened preterm birth and group 2 (n=85) patients with preterm birth; patients of group 2 were divided into two subgroups: group: 2-A (n = 40), patients with premature birth without rupture of amniotic fluid, 2-B group (n = 45), patients with premature birth with rupture of amniotic fluid), the control group consisted of (n = 50) women with a physiological course pregnancy.

Key words: preterm birth, risk factors, immunological markers, pro-inflammatory cytokines, anti-inflammatory cytokines, IL-10, TNF-α, IL-1β.

First page

2

Last page

7

For citation: Sarkisova L.V., Sharopova M.M. - PROGNOSTIC VALUE OF IMMUNOLOGICAL MARKERS IN IMPROVING PRETERM BIRTH OUTCOMES//New Day in Medicine 6(92)2026 2-7 https://newdayworldmedicine.com/en/new_day_medicine/6-92-2026

List of References

  1. Агаян РА. Исходный соматический статус как предиктор преждевременных родов: влияние на репродуктивные результаты: автореф. дис. Москва; 2023. С. 3–25.
  2. Елизарова НН, Артымук НВ, Поленок ЕГ. Иммунологические особенности женщин с преждевременным разрывом плодных оболочек в 22+0–36+6 недель беременности. Фундаментальная и клиническая медицина. 2017;2(3):58–62.
  3. Саркисова ЛВ. Профилактика преждевременных родов посредством определения цитокинов. Вестник врача. 2020:88–91.
  4. Green ES, Arck PC. Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus. Semin Immunopathol. 2020;42(4):413–429. doi:10.1007/s00281-020-00807-y.
  5. Sarkisova L, Karimova N, Hikmatova N, Shodiyev B, Kadyrbayeva M, Suleymanova G. Immunological predictors in predicting premature birth. BIO Web Conf. 2024;121:04011.
  6. Sarkisova LV. Assessment of the risk of preterm birth by assessing the polymorphism of tumor necrosis factor alpha and interleukin 1-beta. J Nat Remedies. 2022;22(1 Suppl 2):95–101.
  7. Sarkisova LV, Yuldasheva RU, Kurbanova ZSh, Aslonova MJ. The role of indicators of ferrokinetics and endogenous erythropoietin in anemia of pregnant women. Am J Med Med Sci. 2020;10(4):262–265. doi:10.5923/j.ajmms.20201004.08.
  8. Sarkisova LV. Interconnection of biochemical and hemodynamic indicators in premature labor. Web of Scientist: International Scientific Research Journal. 2022;3(7):32–34.
  9. Sarkisova LV. Modern approach of assessment of the risk of preterm birth. Am J Med Med Sci. 2021;11(9):630–634. doi:10.5923/j.ajmms.20211109.03.
  10. Sarkisova LV. Premature birth in a modern aspect. Int J Bio-Sci Bio-Technol. 2019;11(10):31–37.
  11. Sarkisova LV. Causes of premature birth and fetters and warnings. Web of Scientist: International Scientific Research Journal. 2022;3(7):32–34.

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