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  • 2 -6 (92) 2026 - Alikulova N.A., Nazarova Z.A. - PREVIOUS TRANSIENT ISCHEMIC ATTACKS AS A FACTOR IN THE SEVERITY OF NEUROLOGICAL DEFICIT IN HEMISPHERIC ISCHEMIC STROKE

2 -6 (92) 2026 - Alikulova N.A., Nazarova Z.A. - PREVIOUS TRANSIENT ISCHEMIC ATTACKS AS A FACTOR IN THE SEVERITY OF NEUROLOGICAL DEFICIT IN HEMISPHERIC ISCHEMIC STROKE

PREVIOUS TRANSIENT ISCHEMIC ATTACKS AS A FACTOR IN THE SEVERITY OF NEUROLOGICAL DEFICIT IN HEMISPHERIC ISCHEMIC STROKE

Alikulova N.A. - Center for the Development of Professional Qualifications of Medical Workers

Nazarova Z.A. - Center for the Development of Professional Qualifications of Medical Workers

Urinova G.M. - Center for the Development of Professional Qualifications of Medical Workers

Resume

Background. The impact of previous transient ischemic attacks (TIAs) on the dynamics of neurological recovery and the state of dynamic autoregulation of cerebral circulation (dACC) after ischemic stroke remains controversial. The aim of the study was to compare changes in neurological status and dACC parameters in patients with first-onset hemispheric carotid stroke depending on the presence of a history of TIA. Material and Methods. Seventy-four patients (40 with TIA, 34 without TIA) aged 40–65 years were examined; The control group consisted of 20 healthy individuals. Neurological outcomes were assessed using the NIHSS, Rankin, and Rivermead scales; dABK was assessed using the autoregulation coefficient (AC) and the reactivity coefficient (KR+) during transcranial Doppler ultrasonography with functional tests. Statistical significance was determined using Student's t-test at p < 0.05. Results. As early as day 3, patients with TIA demonstrated accelerated regression of neurological deficit (NIHSS 4.40 ± 1.1 vs. 6.06 ± 1.1; p = 0.08) and more favorable Rankin score dynamics (2.01 ± 0.28 vs. 2.44 ± 0.30). The coronary artery function remained stable (0.81 ± 0.05) at discharge, while patients without TIAs showed more pronounced impairments in dABMC (coronary artery function = 0.88 ± 0.08). A negative correlation between coronary artery function and stroke severity (r = –0.52) and a positive association between CR+ and the Rivermead index (r = 0.46) were found. Conclusions. Prior TIAs are associated with more rapid clinical improvement and relatively preserved cerebral blood flow autoregulation in the acute period of stroke. Patients without TIAs require more intensive hemodynamic monitoring and personalized prevention, while patients with TIAs can begin rehabilitation interventions earlier.

Keywords: transient ischemic attack; ischemic stroke; dynamic autoregulation of cerebral circulation.

First page

8

Last page

12

For citation:Alikulova N.A., Nazarova Z.A., Urinova G.M. - PREVIOUS TRANSIENT ISCHEMIC ATTACKS AS A FACTOR IN THE SEVERITY OF NEUROLOGICAL DEFICIT IN HEMISPHERIC ISCHEMIC STROKE//New Day in Medicine 6(92)2026 8-12 https://newdayworldmedicine.com/en/new_day_medicine/6-92-2026

List of References

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