• Home
  • NEW DAY MEDICINE
  • 6 (92) 2026
  • 14 -6 (91) 2026 - Agababyan L.R., Shonazarova S.I. - PERSONALIZED APPROACHES TO FERTILITY RESTORATION AFTER OVARIAN ENDOMETRIOSIS SURGERY

14 -6 (91) 2026 - Agababyan L.R., Shonazarova S.I. - PERSONALIZED APPROACHES TO FERTILITY RESTORATION AFTER OVARIAN ENDOMETRIOSIS SURGERY

PERSONALIZED APPROACHES TO FERTILITY RESTORATION AFTER OVARIAN ENDOMETRIOSIS SURGERY

Agababyan L.R. - Samarkand State Medical University

Shonazarova S.I. - Samarkand State Medical University

Resume

Endometriosis is a chronic estrogen-dependent inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity. Ovarian endometriosis is one of the most common forms of the disease and is closely associated with infertility. Surgical treatment of ovarian endometriomas improves clinical symptoms, but may negatively influence ovarian reserve and reproductive potential [1]. Objective: to evaluate the effectiveness of individualized fertility restoration approaches in women after surgery for ovarian endometriosis based on assessment of ovarian reserve, hormonal profile, and endometrial condition. Materials and Methods: the study included 95 reproductive-aged women examined at polyclinics No. 2, 8, 11, and 13 in Samarkand city. The main group consisted of 65 women with a history of surgery for ovarian endometriosis, while the comparison group included 30 women with tubal-peritoneal infertility. Clinical examination, hormonal evaluation (AMH, FSH, LH), ultrasound assessment of ovarian reserve, and endometrial M-echo analysis were performed. Results: women after ovarian endometrioma surgery demonstrated significantly decreased AMH levels and reduced antral follicle count compared with the comparison group. Elevated FSH levels and impaired endometrial parameters were more frequently observed in patients with bilateral ovarian lesions and repeated surgical interventions. Individualized fertility restoration strategies based on ovarian reserve assessment improved treatment selection and reproductive prognosis. Conclusion: comprehensive assessment of ovarian reserve and hormonal status in women after ovarian endometriosis surgery allows the development of personalized fertility restoration algorithms and contributes to optimization of reproductive outcomes.

Keywords: endometriosis; ovarian endometrioma; infertility; ovarian reserve; AMH; fertility restoration; individualized approach.

First page

82

Last page

87

For citation:Agababyan L.R. Shonazarova S.I. - PERSONALIZED APPROACHES TO FERTILITY RESTORATION AFTER OVARIAN ENDOMETRIOSIS SURGERY//New Day in Medicine 6(92)2026 82-87 https://newdayworldmedicine.com/en/new_day_medicine/6-92-2026

List of References

  1. Somigliana E., Berlanda N., Benaglia L., Vigano P., Vercellini P., Fedele L. Surgical excision of endometriomas and ovarian reserve: a systematic review on serum antimüllerian hormone level modifications. Fertility and Sterility. 2012;98(6):1531–1538. https://doi.org/10.1016/j.fertnstert.2012.08.009
  2. Zondervan K.T., Becker C.M., Missmer S.A. Endometriosis. New England Journal of Medicine. 2020;382(13):1244–1256. https://doi.org/10.1056/NEJMra1810764
  3. Giudice L.C., Kao L.C. Endometriosis. Lancet. 2004;364(9447):1789–1799. https://doi.org/10.1016/S0140-6736(04)17403-5
  4. Chapron C., Marcellin L., Borghese B., Santulli P. Rethinking mechanisms, diagnosis and management of endometriosis. Nature Reviews Endocrinology. 2019;15(11):666–682. https://doi.org/10.1038/s41574-019-0245-z
  5. Muzii L., Achilli C., Lecce F., Bianchi A., Franceschetti S., Marchetti C., Perniola G., Panici P.B. Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery. Fertility and Sterility. 2015;103(3):738–743. https://doi.org/10.1016/j.fertnstert.2014.12.101
  6. Raffi F., Metwally M., Amer S. The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis. Journal of Clinical Endocrinology & Metabolism. 2012;97(9):3146–3154. https://doi.org/10.1210/jc.2012-1558
  7. Sanchez A.M., Vanni V.S., Bartiromo L., Papaleo E., Zilberberg E., Candiani M., Orvieto R., Viganò P. Is the oocyte quality affected by endometriosis? A review of the literature. Journal of Ovarian Research. 2017;10(1):43. https://doi.org/10.1186/s13048-017-0341-4
  8. European Society of Human Reproduction and Embryology (ESHRE). Endometriosis guideline. Human Reproduction Open. 2022;2022(2):hoac009. https://doi.org/10.1093/hropen/hoac009
  9. Donnez J., Dolmans M.M. Endometriosis and medical therapy: from progestogens to progesterone resistance to GnRH antagonists. Human Reproduction Update. 2021;27(2):290–304. https://doi.org/10.1093/humupd/dmaa038
  10. Lessey B.A., Kim J.J. Endometrial receptivity in infertility, endometriosis, and implantation failure. Fertility and Sterility. 2017;108(6):961–966. https://doi.org/10.1016/j.fertnstert.2017.10.030

    file

    download