26 -6 (92) 2026 - Vafoyev Sh.F., Shagazatova B.X. - SEMIZLIK VA QANDLI DIABET 2-TURI BILAN OG‘RIGAN BEMORLAR KO‘RSATKICHLARINING SOLISHTIRMA TAHLILI

SEMIZLIK VA QANDLI DIABET 2-TURI BILAN OG‘RIGAN BEMORLAR KO‘RSATKICHLARINING SOLISHTIRMA TAHLILI

Vafoyev Sh.F. - Toshkent Davlat Tibbiyot Universiteti

Shagazatova B.X. - Toshkent Davlat Tibbiyot Universiteti

Resume

Semizlik hamda qandli diabet 2-turi (QD) bilan og‘rigan bemorlarning davolashdan oldin antropometrik, lipid va ichak mikrobiotasi ko‘rsatkichlarini tahlil qilish ushbu tadqiqotning maqsadi hisoblanadi. Tadqiqot material va metodlari. Tadqiqotga davolash boshlanishidan oldin tekshirilgan 75 nafar semizlik (GO‘P-1 agonistlari va bariatrik jarrohlikka rejalashtirilgan) va 52 nafar qandli diabet (QD) 2-turi (metformin buyurilishidan oldingi) bemorlar kiritildi. Bel aylanasi, tana vazni indeksi (TVI), umumiy xolesterin, triglitseridlar, ZPLP- va ZYLP-xolesterin hamda najas mikrobiotasining 19 ta vakili (lg nusxa/ml) baholandi. Natijalar. Semizlik guruhida bel aylanasi, TVI, triglitseridlar va umumiy xolesterin ishonchli darajada yuqori bo‘ldi (barchasi uchun p<0,05; triglitseridlar uchun d=1,66). QD guruhida esa enteropatogen Escherichia coli, Klebsiella oxytoca, Candida spp., Enterococcus spp. va Lactobacillus spp. miqdori yuqori bo‘lib, opportunistik flora ustunligi qayd etildi. Eng axborotli yagona belgi triglitseridlar bo‘ldi (AUC=0,908). Mikrobiota ko‘rsatkichlaridan tashkil topgan ko‘p omilli model guruhlarni yuqori aniqlikda ajratdi (AUC=0,947). Xulosa. Davolashdan oldingi bosqichda semizlik va QD ikkilasi ham turli metabolik-mikrobiologik fenotipni namoyon etadi: semizlikda metabolik-lipid yuklama, QD da esa ifodalangan disbioz ustunlik qiladi.

Kalit so‘zlar: semizlik, qandli diabet 2-turi, ichak mikrobiotasi, disbioz, triglitseridlar, lipid profili, korrelyatsion tahlil, GO‘P-1 agonistlari.

First page

165

Last page

172

For citation:Vafoyev Sh.F., Shagazatova B.X. - SEMIZLIK VA QANDLI DIABET 2-TURI BILAN OG‘RIGAN BEMORLAR KO‘RSATKICHLARINING SOLISHTIRMA TAHLILI//New Day in Medicine 6(92)2026 165-172 https://newdayworldmedicine.com/en/new_day_medicine/6-92-2026

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