49 -6 (92) 2026 - Mukhamedova Sh.T., Achilova D.N. - ADVANCING PEDIATRIC INSECT ALLERGY CARE: THE ROLE OF COMPONENT-RESOLVED DIAGNOSTICS AND IMMUNOTHERAPY IN CENTRAL ASIA

ADVANCING PEDIATRIC INSECT ALLERGY CARE: THE ROLE OF COMPONENT-RESOLVED DIAGNOSTICS AND IMMUNOTHERAPY IN CENTRAL ASIA

Mukhamedova Sh.T. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Achilova D.N. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Naimova Sh.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Rustamov B.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Jumaev F.E. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Kasimova N.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Insect venom allergy (Hymenoptera venom allergy, HVA) is a leading cause of anaphylaxis in the pediatric population. In the arid and hot climate of Uzbekistan, the high activity of stinging insects makes this a significant public health concern. This review synthesizes global evidence on diagnostic innovations and the efficacy of venom immunotherapy (VIT) to inform strategies for improving pediatric care in Central Asia. Methods: A systematic review was conducted in accordance with the PRISMA 2020 guidelines. A comprehensive literature search was performed across PubMed, Scopus, and the Cochrane Library for studies published between 2016 and 2026 focusing on pediatric HVA, component-resolved diagnostics (CRD), and VIT. Fifteen studies were selected for final qualitative and quantitative synthesis. Results: The total sample size across the selected studies was 1,482 patients (aged 3–18 years). Component-resolved diagnostics (CRD) using markers such as Ves v 5 and Api m 1 increased diagnostic accuracy in 85% of cases involving double sensitization. VIT demonstrated a protective efficacy of 95–98% for vespid venom and 84–91% for honeybee venom. Regional data from the Bukhara region (Uzbekistan) indicate that insect allergy accounts for 11% of acute allergic reactions in children, frequently associated with Vespa orientalis stings. The safety profile in children was superior to that in adults, with systemic reactions occurring in less than 1% of cases. Conclusions: Managing pediatric insect allergy requires a transition toward molecular diagnostics and expanded access to VIT. Drawing parallels with the development of specialized fields like pediatric gynecology, we emphasize the urgent need for specialized training programs for pediatric allergists and the establishment of regional reference centers in Uzbekistan to bridge the gap between primary care and high-tech immunotherapy.

Keywords: Insect allergy, Anaphylaxis, Pediatric allergology, Allergen-specific immunotherapy (ASIT), Component-resolved diagnostics (CRD), Uzbekistan, Central Asia, Vespa orientalis.

First page

299

Last page

303

For citation:Mukhamedova Sh.T., Achilova D.N., Naimova Sh.A., Rustamov B.B., Jumaev F.E., Kasimova N.A. - ADVANCING PEDIATRIC INSECT ALLERGY CARE: THE ROLE OF COMPONENT-RESOLVED DIAGNOSTICS AND IMMUNOTHERAPY IN CENTRAL ASIA//New Day in Medicine 6(92)2026 299-303 https://newdayworldmedicine.com/en/new_day_medicine/6-92-2026

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