62 -6 (92) 2026 - Seytbaev B.R., Adilbekova D.B., Ahrorov A.A., Toshpulatov S.S. - ONADAGI QANDLI DIABET XASTALIGI SHAROITIDA TUG‘ILGAN AVLOD SIYDIK AYIRUV TIZIMI A’ZOLARIDAGI O‘ZGARISHLAR TO‘G‘RISIDAGI ZAMONAVIY TASAVVURLAR

ONADAGI QANDLI DIABET XASTALIGI SHAROITIDA TUG‘ILGAN AVLOD SIYDIK AYIRUV TIZIMI A’ZOLARIDAGI O‘ZGARISHLAR TO‘G‘RISIDAGI ZAMONAVIY TASAVVURLAR

Seytbaev B.R., Adilbekova D.B., Ahrorov A.A., Toshpulatov S.S. - Toshkent Davlat Tibbiyot Universiteti

Rezyume

Ushbu adabiyotlar sharhi oxirgi yillarda olib borilgan ilmi-tadqiqot ishlari asosida onadagi qandli diabet (QD) sharoitida tug‘ilgan avlodning siydik ayiruv tizimi (SAT) a’zolarida yuzaga keladigan strukturaviy, funksional va molekulyar o‘zgarishlarni tahlil qilishga bag‘ishlangan. Sharh nefropatiyaning patogenetik mexanizmlari, oksidativ stress, epigenetik dasturlash, RAAS tizimining buzilishi va giperglikemiyaning glomerulyar hamda tubulyar strukturalarga ta’siri masalalarini qamrab olgan bo‘lib, zamonaviy diagnostik yondashuvlar, biomarkerlar va terapevtik strategiyalar chuqur tizimli tahlil qilingan. Natijalarga ko‘ra, ona qandli diabeti avlodda nefron sonining kamayishi, glomerulyar filtratsiya tezligining pasayishi va renin-angiotenzin tizimining programmalashtiruvchi o‘zgarishlariga olib keladi, bu esa kelajakda surunkali buyrak kasalligiga moyillikni oshiradi.

Kalit so‘zlar: qandli diabet, homiladorlik, siydik ayiruv tizimi, nefropatiya, epigenetik dasturlash, oksidativ stress, nefron soni, glomeruloskleroz, RAAS, biomarker, fetal dasturlash, diabetik embriopatiya

First page

363

Last page

368

For citation:Seytbaev B.R., Adilbekova D.B., Ahrorov A.A., Toshpulatov S.S. - ONADAGI QANDLI DIABET XASTALIGI SHAROITIDA TUG‘ILGAN AVLOD SIYDIK AYIRUV TIZIMI A’ZOLARIDAGI O‘ZGARISHLAR TO‘G‘RISIDAGI ZAMONAVIY TASAVVURLAR//New Day in Medicine 6(92)2026 363-368 https://newdayworldmedicine.com/en/new_day_medicine/6-92-2026

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