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  • 6 -3 (41) 2022 — Badritdinova M.N., Orziqulova Sh.A. — MECHANISMS OF THE KIDNEY DAMAGE IN CASE OF OBESITY AND METABOLIC SYNDROME

6 -3 (41) 2022 — Badritdinova M.N., Orziqulova Sh.A. — MECHANISMS OF THE KIDNEY DAMAGE IN CASE OF OBESITY AND METABOLIC SYNDROME

MECHANISMS OF THE KIDNEY DAMAGE IN CASE OF OBESITY AND METABOLIC SYNDROME

Badritdinova M.N., Bukhara State Medical Institute named after Abu Ali ibn Sina

Orziqulova Sh.A. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Obesity and metabolic syndrome influence the functions of body’s systems, provoke a progressive kidney damage and are development factors of chronic nephron number in reference to body mass. A long_term impact of these factors leads to glomerulosclerosis and chronic renal failure development. The detection of kidney disease. The kidney damage in case of obesity is related to the adipokine production failure, activation of the renin_angiotensin system, chronic inflammation, dyslipidemia, violation of kidney hemodynamics, reduction of early signs and biomarkers of the kidney damage at children is a necessary condition for prevention of the renal failure development.

Key words: оbesity; metabolic syndrome; nephropathy; chronic kidney disease.

First page

36

Last page

38

For citation: Badritdinova M.N., Orziqulova Sh.A. MECHANISMS OF THE KIDNEY DAMAGE IN CASE OF OBESITY AND METABOLIC SYNDROME //New Day in Medicine 3(41)2022 36-38 https://clck.ru/eih4X

LIST OF REFERENCES:

  1. Jungheim E.S., Travieso J.L., Carson K.R., Moley K.H. Obesity and reproductive function. Obstetrics and gynecology clinics of North America. 2012;
  2. Jiao L., Berrington de Gonzalez A., Hartge P., Pfeiffer R.M., Park Y., Freedman D.M. et al. Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts. Cancer Causes & Control. 2010; 21(8): 1305_1314.
  3. Saginova E.A., Fomin V.V., Moiseev S.V., Lebedeva M.V.. Renal affection in obesity. Terapevticheskij arkhiv. 2007; 79(6): 88_93. Russian (Сагинова Е.А., Фомин В.В., Моисеев С.В., Лебедева М.В. Поражение почек при ожирении //Терапевтический архив. 2007. T. 79, № 6. С. 88_93.)
  4. Halpern A., Mancini M.C., Magalhaes M.E., Fisberg M., Radominski R., Bertolami M.C. et al. Metabolic syndrome, dyslipidemia, hypertension and2 types diabetes in youth: from diagnosis to treatment. Diabetology & Metabolic Syndrome. 2010; 2: 55. DOI:10.1186/1758_5996_2_55.
  5. Griffith M.L., Younk L.M., Davis S.N.. Visceral adiposity, insulin resistance, and type 2 diabetes. //American J. Life Med. 2010; 4: 230_243.
  6. Kovesdy C.P., Furth S., Zoccali C. Obesity and kidney disease: hidden consequences of the epidemic. Clinical nephrology. 2017; (1): 3_11. Russi_an (Ковесди К.П., Фурс С., Зоккали К. Ожирение и заболевание почек: скрытые последствия эпидемии //Клиническая нефрология. 2017. № 1. С. 3_11.)
  7. WHO Factsheet Updated 2016. Obesity and overweight. http://www.who.int/mediacentre/factsheets/fs311/ru/ (дата обращения 28.02.2018)
  8. Smirnova N.N., Kuprienko N.B. Diabetic nephropathi in pediatrics. Nephrology (Saint_Petersburg). 2013; 17(6): 37_45. Russian (Смирнова Н.Н., Куприенко Н.Б. Нефропатия ожирения в педиатрии //Нефрология. 2013. Т. 17, № 6. С. 37_45.)
  9. Foster M.C., Hwang S.J., Larson M.G., Lichtman J.H., Parikh N.I., Vasan R.S. et al. Overweight, obesity and the development of stage 3 CKD: the Fra_mingham Heart Study. Am J Kidney Dis. 2008; 52(1): 39_48. DOI: 10.1053/j.ajkd.2008.03.003.
  10. Freemark M. Pediatric Obesity: Etiology, Pathogenesis and Treatment. Humana Press, New York, 2010; 27_30.
  11. Yamagishi Si, Edelstein D., Du X.L., Каneda Y., Guzman M., Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein_1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem. 2001; 276(27): 25096_25100.
  12. Werner N., Nickenig G. From fat fighter to risk factor: the zigzag trek of leptin. Arteriosclerosis, Thrombosis and Vascular Biology. 2004; 24:7_9. DOI: 10.1161/01.ATV.0000110908.43721.
  13. Stengel B., Tarver_Carr M.E., Powe N.R., Eberhardt M.S., Brancati F.L. Lifestyle factors, obesity and the risk of chronic kidney disease. //Epidemiology.2003;14(4):479_487.DOI:10.1097/01.EDE.0000071413.55296.
  14. Chen J., Muntner P., Hamm L.L., Jones D.W., Batuman V., Fonseca V. et al. The metabolic syndrome and chronic kidney disease in U. S. adults. Ann. Intern. Med. 2004; 140(3): 167_174.
  15. Chen J., Gu D., Chen C.S., Wu X., Hamm L.L., Muntner P. et al. Association between the metabolic syndrome and chronic kidney disease in Chinese adults. //Nephrol. Dial. Transplant. 2007; 22(4): 1100_1106. DOI:10.1093/ndt/gfl759

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