• Home
  • NEW DAY MEDICINE
  • 6 (92) 2026
  • 88 -6 (92) 2026 - Xodjiyeva D.T., Akhmedova D.B., Kuliyev H.Sh. - TOWARD A PERSONALIZED RTMS ALGORITHM FOR FACIAL NERVE NEUROPATHY: INTEGRATION OF CLINICAL SCORES, IMMUNE MARKERS AND ENMG

88 -6 (92) 2026 - Xodjiyeva D.T., Akhmedova D.B., Kuliyev H.Sh. - TOWARD A PERSONALIZED RTMS ALGORITHM FOR FACIAL NERVE NEUROPATHY: INTEGRATION OF CLINICAL SCORES, IMMUNE MARKERS AND ENMG

TOWARD A PERSONALIZED RTMS ALGORITHM FOR FACIAL NERVE NEUROPATHY: INTEGRATION OF CLINICAL SCORES, IMMUNE MARKERS AND ENMG

Xodjiyeva D.T., Akhmedova D.B., Kuliyev H.Sh. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Objective: To develop and expand a personalized rehabilitation algorithm for facial nerve neuropathy by integrating clinical scales, immune-inflammatory biomarkers and electroneuromyographic (ENMG) markers. Methods: A comparative dataset of 103 patients treated with 1 Hz rTMS, 10 Hz rTMS or conventional therapy was synthesized into clinically usable decision points. Results: The 10 Hz protocol demonstrated the most consistent superiority across the clinical, immune and ENMG domains: House–Brackmann improvement 86.5%, Sunnybrook gain approximately 100%, more pronounced Yanagihara recovery, IL-6 reduction by 33–35%, CRP reduction by about 30% and M-response amplitude increase by 53%. The 1 Hz protocol also outperformed conventional therapy and appeared more relevant when excessive activity, hypertonus or synkinesis risk dominated. Conclusion: A personalized algorithm can reduce empiricism, support more rational rTMS selection and improve the targeting of neurorehabilitation.

Keywords: personalized rehabilitation, rTMS algorithm, facial nerve neuropathy, IL-6, CRP, ENMG, neurorehabilitation, Bell’s palsy.

First page

421

Last page

526

For citation:Xodjiyeva D.T., Akhmedova D.B., Kuliyev H.Sh. - TOWARD A PERSONALIZED RTMS ALGORITHM FOR FACIAL NERVE NEUROPATHY: INTEGRATION OF CLINICAL SCORES, IMMUNE MARKERS AND ENMG//New Day in Medicine 6(92)2026 421-526 https://newdayworldmedicine.com/en/new_day_medicine/6-92-2026

List of References

  1. Tiemstra JD, Khatkhate N. Bell’s palsy: diagnosis and management. Am Fam Physician. 2023;107(4):364-372.
  2. Gardner S, Garber L, Grossi J. Bell’s palsy: description, diagnosis, and current management. Cureus. 2025;17(1):e77656. doi:10.7759/cureus.77656.
  3. Liu C, Wang Y, Han T, et al. Efficacy of repetitive transcranial magnetic stimulation in treating patients with Bell’s palsy: a randomized controlled trial. Front Neurol. 2022;13:930027. doi:10.3389/fneur.2022.930027.
  4. Song YJ, Lee SJ, Lee MH. Transcranial magnetic stimulation for facial nerve palsy: meta-analysis. Clin Rehabil. 2021;35(12):1583-1591. doi:10.1177/02692155211031274.
  5. Kleinveld HA, Stalpers XL, Ket JCF, van der Veen EL, Dikkers FG. The value of electrophysiological tests in Bell’s palsy: a systematic review. Brain Sci. 2023;13(4):624. doi:10.3390/brainsci13040624.
  6. Guntinas-Lichius O, Volk GF, Olsen KD, et al. Facial nerve electrodiagnostics for patients with facial nerve palsy: a clinical practice guideline. Laryngoscope Investig Otolaryngol. 2020;5(3):521-530. doi:10.1002/lio2.386.
  7. Khan AJ, Szczepura A, Palmer S, et al. Physical therapy for facial nerve paralysis (Bell’s palsy): an updated and extended systematic review. Clin Rehabil. 2022;36(11):1424-1449. doi:10.1177/02692155221110727.

    file

    download