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  • 45 -7 (93) 2026 - Javohir Idibekov - ACUTE HYPOXEMIC RESPIRATORY FAILURE IN THE ICU: PREDICTORS OF PROLONGED MECHANICAL VENTILATION AND 30-DAY MORTALITY

45 -7 (93) 2026 - Javohir Idibekov - ACUTE HYPOXEMIC RESPIRATORY FAILURE IN THE ICU: PREDICTORS OF PROLONGED MECHANICAL VENTILATION AND 30-DAY MORTALITY

ACUTE HYPOXEMIC RESPIRATORY FAILURE IN THE ICU: PREDICTORS OF PROLONGED MECHANICAL VENTILATION AND 30-DAY MORTALITY

Javohir Idibekov - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Acute hypoxemic respiratory failure (AHRF) is one of the most frequent indications for admission to the intensive care unit (ICU) and a leading cause of ICU mortality worldwide. Mechanical ventilation (MV) remains the cornerstone of respiratory support in AHRF; however, prolonged ventilation is independently associated with ventilator-induced lung injury, ventilator-associated pneumonia, diaphragmatic dysfunction, and increased mortality. The identification of early predictors of prolonged MV and 30-day mortality in AHRF patients is therefore of critical clinical importance, particularly in Central Asian ICUs where evidence-based risk stratification tools derived from local populations are lacking.

Keywords: acute hypoxemic respiratory failure, mechanical ventilation, ARDS, PaO₂/ PaCO₂ ratio, ventilator-associated pneumonia, lung-protective ventilation, intensive care unit, 30-day mortality, weaning.

First page

309

Last page

313

For citation:Javohir Idibekov - ACUTE HYPOXEMIC RESPIRATORY FAILURE IN THE ICU: PREDICTORS OF PROLONGED MECHANICAL VENTILATION AND 30-DAY MORTALITY//New Day in Medicine 7(93)2026 309-313 https://newdayworldmedicine.com/en/new_day_medicine/7-93-2026

List of References

  1. Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al.; LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315(8):788-800. doi: 10.1001/jama.2016.0291
  2. ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307(23):2526-2533. doi: 10.1001/jama.2012.5669
  3. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019;5(1):18. doi: 10.1038/s41572-019-0069-0
  4. Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1301-1308. doi: 10.1056/NEJM200005043421801
  5. MacIntyre NR, Epstein SK, Carson S, Scheinhorn D, Christopher K, Muldoon S. Management of patients requiring prolonged mechanical ventilation: report of a NAMDRC consensus conference. Chest. 2005;128(6):3937-3954. doi: 10.1378/chest.128.6.3937
  6. Fleischmann C, Scherag A, Adhikari NKJ, Hartog CS, Tsaganos T, Schlattmann P, et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259-272. doi: 10.1164/rccm.201504-0781OC
  7. Amato MBP, Meade MO, Slutsky AS, Brochard L, Costa ELV, Schoenfeld DA, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015;372(8):747-755. doi: 10.1056/NEJMsa1410639
  8. Villar J, Pérez-Méndez L, López J, Belda J, Blanco J, Saralegui I, et al. An early PEEP/FIO₂ trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2007;176(8):795-804. doi: 10.1164/rccm.200610-1534OC
  9. Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, et al.; Early PN Investigators. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA. 2013;309(20):2130-2138. doi: 10.1001/jama.2013.5124
  10. Klompas M, Branson R, Eichenwald EC, Greene LR, Howell MD, Lee G, et al. Strategies to prevent ventilator-associated pneumonia in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35(8):915-936. doi: 10.1086/677144

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