35 -8 (94) 2026 - Navruzova Sh.I., Bahodirov B.Sh. - BRONXIAL ASTMALI BOLALARDA BURUN-HALQUM MIKROBIOTASINING ANTIBIOTIKLARGA CHIDAMLILIGI

BRONXIAL ASTMALI BOLALARDA BURUN-HALQUM MIKROBIOTASINING ANTIBIOTIKLARGA CHIDAMLILIGI

Navruzova Sh.I. - Abu Ali ibn Sino nomidagi Buxoro davlat tibbiyot instituti

Bahodirov B.Sh. - Navoiy davlat universiteti

Rezume

Bronxial astma bilan kasallangan bolalarda takroriy antibakterial terapiya burun-halqum mikrobiotasida chidamli shtammlar tanlanishiga olib keladi. Tadqiqotda 60 nafar boladan ajratilgan 87 ta bakterial izolyatning 36 ta antibakterial preparatga sezgirligi o‘rganildi. Empirik terapiya uchun preparatlar kanamitsin (83,9%), linkomitsin (78,9%) va sefazolin (73,2%) bo‘lib, seftriakson (29,6%) va norfloksatsin (23,5%) tavsiya etilmaydi. Eng chidamli patogen Klebsiella pneumoniae bo‘ldi (MAR indeksi 0,465).

Kalit so‘zlar: bronxial astma, bolalar, burun-halqum mikrobiotasi, antibiotiklarga chidamlilik, MAR indeksi, MDR, empirik terapiya.

First page

259

Last page

262

For citation:Navruzova Sh.I., Bahodirov B.Sh. - BRONXIAL ASTMALI BOLALARDA BURUN-HALQUM MIKROBIOTASINING ANTIBIOTIKLARGA CHIDAMLILIGI//New Day in Medicine 8(94)2026 259-262 https://newdayworldmedicine.com/en/new_day_medicine/8-94-2026

ADABIYOTLAR RO’YXATI

1. Abdullayev S. Bolalarda bronxial astmaning allergik rinit va atopik dermatit bilan komorbidlik fenotiplarining klinik-immunologik va biokimyoviy xususiyatlari [dissertation]. Toshkent; 2025. 60 p.
2. Al-Iede M, Ayyad DM, Etoom RA, Aldameiry RH, Toubasi AA. The prevalence and risk factors of methicillin-resistant Staphylococcus aureus among pediatric populations: a systematic review and meta-analysis. Eur J Pediatr. 2024;183(9):3679-3687. doi:10.1007/s00431-024-05672-7.
3. Assad Z, Cohen R, Varon E, Levy C, Bechet S, Corrard F, et al. Antibiotic resistance of Haemophilus influenzae in nasopharyngeal carriage of children with acute otitis media and in middle ear fluid from otorrhea. Antibiotics (Basel). 2023;12(11):1605. doi:10.3390/antibiotics12111605.
4. Attaianese F, Privato R, Montagnani C, Stivala M, Trapani S, Galli L, et al. Antibiotic optimization in hospitalized children with non-severe community-acquired pneumonia: lessons from an antimicrobial stewardship intervention (2022-2024). Front Pediatr. 2025;13:1660776. doi:10.3389/fped.2025.1660776.
5. Du Q, Xu Q, Pan F, Shi Y, Yu F, Zhang T, et al. Association between intestinal colonization and extraintestinal infection with carbapenem-resistant Klebsiella pneumoniae in children. Microbiol Spectr. 2023;11(2):e04088-22. doi:10.1128/spectrum.04088-22.
6. European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 14.0. Växjö: EUCAST; 2024.
7. GBD 2021 Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050. Lancet. 2024;404(10459):1199-1226. doi:10.1016/S0140-6736(24)01867-1.
8. Global Initiative for Asthma. Global strategy for asthma management and prevention: 2024 update. Fontana, WI: Global Initiative for Asthma; 2024. 260 p.
9. Kalasikam M, Jimenez-Truque N, Kloek AB, Banerjee R. Antibiotic overuse in a contemporary cohort of children hospitalized with influenza, RSV, or SARS-CoV-2: a retrospective cohort study. BMC Pediatr. 2025;25(1):759. doi:10.1186/s12887-025-06165-8.
10. Rybak A, Levy C, Ouldali N, Bonacorsi S, Béchet S, Delobbe JF, et al. Dynamics of antibiotic resistance of Streptococcus pneumoniae in France: a pediatric prospective nasopharyngeal carriage study from 2001 to 2022. Antibiotics (Basel). 2023;12(6):1020. doi:10.3390/antibiotics12061020.
11. World Health Organization. WHO bacterial priority pathogens list, 2024: bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance. Geneva: World Health Organization; 2024. 72 p. ISBN 978-92-4-009346-1.

    file

    download