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  • 52 -8 (94) 2026 - Sharipova Sh.U., Tuksanova D.I. - ERTA PREEKLAMPSIYA RIVOJLANISH XAVFI BO‘LGAN HOMILADOR AYOLLARDA KOAGULOGRAMMA VA GEMATOLOGIK KO‘RSATKICHLARNING TRIMESTRLAR BO‘YICHA O‘ZGARISH DINAMIKASI

52 -8 (94) 2026 - Sharipova Sh.U., Tuksanova D.I. - ERTA PREEKLAMPSIYA RIVOJLANISH XAVFI BO‘LGAN HOMILADOR AYOLLARDA KOAGULOGRAMMA VA GEMATOLOGIK KO‘RSATKICHLARNING TRIMESTRLAR BO‘YICHA O‘ZGARISH DINAMIKASI

ERTA PREEKLAMPSIYA RIVOJLANISH XAVFI BO‘LGAN HOMILADOR AYOLLARDA KOAGULOGRAMMA VA GEMATOLOGIK KO‘RSATKICHLARNING TRIMESTRLAR BO‘YICHA O‘ZGARISH DINAMIKASI

Sharipova Sh.U., Tuksanova D.I. - Abu Ali ibn Sino nomidagi Buxoro davlat tibbiyot instituti

Rezyume

Maqsad. Preeklampsiya (PE) tizimli endotelial disfunksiya va gemostaz muvozanatining buzilishi bilan kechadi. Tadqiqotda erta PE xavfi bo‘lgan ayollarda gematologik va koagulogramma ko‘rsatkichlarining trimestrlar bo‘yicha dinamikasi o‘rganildi. Material va usullar. Prospektiv qiyosiy tadqiqotga 102 nafar homilador ayol jalb etildi: nazorat guruhi (n=30), erta tashxislangan va majmuaviy davolash olib borilgan asosiy guruh (n=32) va erta tashxislanmagan guruh (n=40). Umumiy qon tahlili, siydik oqsili, fibrinogen, protrombin indeksi (PI), FQTV, XMN va protrombin vaqti (PTV) trimestrlar kesimida baholandi. Ma’lumotlar SPSS 26.0 da ANOVA, Kruskal–Uollis va χ² mezonlari bilan qayta ishlandi; p<0,05 ishonchli deb qabul qilindi. Natijalar. III trimestrda 3-guruhda anemiya (gemoglobin 80,1±6,2 g/l), nisbiy trombotsitopeniya (150,9±14,2×10⁹/l) va rang ko‘rsatkichining pasayishi (0,70) aniqlandi. Giperkoagulyatsiya yaqqol ifodalandi: fibrinogen 7,6±1,0 g/l gacha, PI 148% gacha oshdi, PTV esa 8,7 s gacha qisqardi (p<0,05). Proteinuriya 3-guruh bemorlarining qariyb 90% ida qayd etildi. Barcha o‘zgarishlar davolangan 2-guruhda ishonchli darajada yumshoqroq bo‘ldi (p<0,05). Xulosa. Erta PE xavfida anemiya, trombotsitopeniya va giperkoagulyatsiya kasallik og‘irligiga mutanosib kuzatilib, DVS-sindrom rivojlanishi xavfidan dalolat beradi. Erta tashxislash va majmuaviy davolash koagulopatik o‘zgarishlarni ishonchli darajada yumshatadi.

Kalit so‘zlar: preeklampsiya, koagulogramma, giperkoagulyatsiya, fibrinogen, protrombin indeksi, trombotsitopeniya, EChT, endotelial disfunksiya, erta tashxislash, homiladorlik.

First page

373

Last page

382

For citation:Sharipova Sh.U., Tuksanova D.I. - ERTA PREEKLAMPSIYA RIVOJLANISH XAVFI BO‘LGAN HOMILADOR AYOLLARDA KOAGULOGRAMMA VA GEMATOLOGIK KO‘RSATKICHLARNING TRIMESTRLAR BO‘YICHA O‘ZGARISH DINAMIKASI//New Day in Medicine 8(94)2026 373-382 https://newdayworldmedicine.com/en/new_day_medicine/8-94-2026

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