78 -8 (94) 2026 - Turniyozov A.A., Xudoyberdiyev D.K. - HISTOMORPHOLOGICAL CHANGES IN CARDIAC TISSUE UNDER THE INFLUENCE OF GENERAL ANESTHESIA FOLLOWING SOFT TISSUE INJURY OF THE LOWER LIMB IN OUTBRED WHITE RATS

HISTOMORPHOLOGICAL CHANGES IN CARDIAC TISSUE UNDER THE INFLUENCE OF GENERAL ANESTHESIA FOLLOWING SOFT TISSUE INJURY OF THE LOWER LIMB IN OUTBRED WHITE RATS

Turniyozov A.A., Xudoyberdiyev D.K. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The analysis of morphological changes in the cardiac tissue following the effects of general anesthesia after experimental soft tissue injury of the right hind limb in 16-month-old outbred white rats demonstrated that this age group exhibited increased vascular permeability accompanied by plasmorrhagia, development of interstitial edema, and swelling of connective tissue fibers. Histochemical examination using toluidine blue staining revealed the accumulation of acidic mucopolysaccharides in the perivascular region. In addition, small lipid droplets were detected in the sarcoplasm of cardiomyocytes, a finding uncharacteristic of this age and indicative of the early onset of metabolic disturbances and reversible protein denaturation (dystrophic changes). Morphometric analysis of cardiac tissue following experimental injury and exposure to general anesthesia showed a 5.8% increase in the area occupied by coarse fibrous structures. The area occupied by blood vessels increased by 5.62%, reflecting vascular congestion as well as sclerotic and dystrophic changes in the vascular wall. Furthermore, the muscular component decreased by 6.36% compared with the control group due to the development of atrophic changes.

Keywords: outbred white rats, lower limb, soft tissue, injury, general anesthesia, cardiac tissue, histomorphological changes.

First page

591

Last page

601

For citation:Turniyozov A.A., Xudoyberdiyev D.K. - HISTOMORPHOLOGICAL CHANGES IN CARDIAC TISSUE UNDER THE INFLUENCE OF GENERAL ANESTHESIA FOLLOWING SOFT TISSUE INJURY OF THE LOWER LIMB IN OUTBRED WHITE RATS//New Day in Medicine 8(94)2026 591-601 https://newdayworldmedicine.com/en/new_day_medicine/8-94-2026

LIST OF REFERENCES

1. Барминский А. В., Егоров А. Н., Киров М. Ю. Методики регионарной анальгезии при абдоминальных вмешательствах в педиатрии // Вестник анестезиологии и реаниматологии. 2024:21(1):110–117.
2. Васильков В. Г. и др. Опыт применения различных методик регионарной анестезии в хирургии и травматологии // Медицинский алфавит. 2017:2(17):30–34.
3. Гурова С.В., Миндарь М.В., Ходакова Д.В. Современные аспекты в области анестезии мелких лабораторных животных // Южно–российский онкологический журнал. 2022:3:55–63.
4. Заболотских И. Б. и др. Прогнозирование кардиального риска в абдоминальной хирургии: результаты наблюдательного многоцентрового исследования // Комплексные проблемы сердечно–сосудистых заболеваний. 2024:13(2):176–195.
5. Королев М. В. и др. Анестезия при артроскопических операциях на нижних конечностях у пожилых пациентов // Инновационная медицина Кубани. 2020:4(20):65–72.
6. Лутай Ю. А. и др. Основные подходы к снижению периоперационных кардиальных осложнений при внесердечных хирургических вмешательствах //Крымский терапевтический журнал. 2023:1:40–46

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