54 -9 (95) 2026 - Saipova D.S., Egamberdieva D. - INTEGRATIVE MSCT–MICROBIOTA PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A CROSS-SECTIONAL STUDY

INTEGRATIVE MSCT–MICROBIOTA PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A CROSS-SECTIONAL STUDY

Saipova D.S. - Tashkent State Medical University, "Republican Scientific and Applied Medical Center of Specialized Therapy and Medical Rehabilitation" DM

Egamberdieva D. - Tashkent State Medical University

Resume

Background: Chronic obstructive pulmonary disease (COPD) is structurally and microbiologically heterogeneous, but multislice computed tomography (MSCT) findings are rarely integrated with oropharyngeal and intestinal microbiota data in the same patients. Objective: To derive integrative MSCT-microbiota phenotypes of COPD and characterise their structural, functional, inflammatory, microbiological and psycho-neurovegetative profiles. Methods: In this single-centre cross-sectional study, 180 patients with COPD and 30 controls underwent MSCT, spirometry, oropharyngeal and stool culture with MALDI-TOF identification, measurement of CRP, IL-6 and TNF-alpha, heart-rate variability (HRV), and the MoCA, HADS and SGRQ instruments. Patients were assigned to one mutually exclusive MSCT-microbiota phenotype using a hierarchical rule prioritising bronchiectasis and resistant flora. Results: Four phenotypes were identified: inflammatory-dysbiotic (37.8%, n=68), bronchitic-colonisation (35.6%, n=64), emphysematous-dysbiotic (13.9%, n=25) and bronchiectatic-resistant (12.8%, n=23). The bronchiectatic-resistant phenotype had the lowest FEV1 (23%), the highest CRP (103 mg/L), the lowest SDNN (37.1±11.2 ms) and the lowest MoCA score (19.4±3.3), and by definition carried bronchiectasis in 100% of cases (all p<0.001-0.05 across phenotypes). Combined oropharyngeal-intestinal colonisation was concentrated in the bronchitic-colonisation phenotype (75.0% of its patients) and was absent by definition from the inflammatory-dysbiotic phenotype. Conclusion: Integrating MSCT with dual-compartment microbiota data identifies four clinically distinct COPD phenotypes with different dominant pathogenetic mechanisms, which may help target antimicrobial stewardship and probiotic correction.

Keywords: chronic obstructive pulmonary disease; multislice computed tomography; phenotype; oropharyngeal microbiota; intestinal dysbiosis; bronchiectasis.

First page

356

Last page

361

For citation:Saipova D.S., Egamberdieva D. - INTEGRATIVE MSCT–MICROBIOTA PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A CROSS-SECTIONAL STUDY//New Day in Medicine 9(95)2026 356-361 https://newdayworldmedicine.com/en/new_day_medicine/9-95-2026

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