82 -9 (95) 2026 - Muhitdinova H.N., Hamrayeva G.Sh., Alauatdinova G.I. - INFLUENCE OF BURN TOXEMIA ON RESPIRATORY FUNCTION AS ASSESSED BY CIRCADIAN RHYTHMS OF RESPIRATORY RATE AND PERIPHERAL OXYGEN SATURATION IN CHILDREN AGED 7-18 YEARS

INFLUENCE OF BURN TOXEMIA ON RESPIRATORY FUNCTION AS ASSESSED BY CIRCADIAN RHYTHMS OF RESPIRATORY RATE AND PERIPHERAL OXYGEN SATURATION IN CHILDREN AGED 7-18 YEARS

Muhitdinova H.N., Hamrayeva G.Sh., Alauatdinova G.I. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Resume

This study evaluated respiratory adaptation during the toxemia phase of severe burn disease using circadian characteristics of respiratory rate (RR) and peripheral oxygen saturation (SpO₂) in 26 children aged 7.1–18 years. Patients were stratified into three groups according to intensive care unit (ICU) stay: Group 1, n=12 (≤10 days); Group 2, n=7 (11–20 days); and Group 3, n=7 (>21 days). Hourly RR and SpO₂ were analyzed with assessment of mesor, amplitude, acrophase shifts, and rhythm inversion. On admission, the RR mesor was 21.3±0.8, 20.7±0.6, and 25.0±3.8 breaths/min in Groups 1, 2, and 3, respectively. The mean RR mesor during the observation period was highest in Group 3 (23.7±0.7 breaths/min). Mean SpO₂ remained high across groups (97.9±0.2%), but the first-day amplitude of SpO₂ fluctuations was greatest in Group 3 (2.3%). The longest inversion of the SpO₂ circadian rhythm was also observed in Group 3 (41% of the observation period). The RR–SpO₂ relationship was most consistently positive in Group 1, less stable in Group 2, and not significant in Group 3. These findings suggest that increasing burn severity and longer ICU treatment are associated with greater circadian disorganization of respiratory regulation and reduced coupling between ventilatory response and oxygenation.

Keywords: severe burns, children, burn toxemia, respiratory rate, peripheral oxygen saturation, circadian rhythm, acrophase, intensive care.

First page

558

Last page

564

For citation:Muhitdinova H.N., Hamrayeva G.Sh., Alauatdinova G.I. - INFLUENCE OF BURN TOXEMIA ON RESPIRATORY FUNCTION AS ASSESSED BY CIRCADIAN RHYTHMS OF RESPIRATORY RATE AND PERIPHERAL OXYGEN SATURATION IN CHILDREN AGED 7-18 YEARS//New Day in Medicine 9(95)2026 558-564 https://newdayworldmedicine.com/en/new_day_medicine/9-95-2026

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