58 -10 (96) 2026 - Dehqonov Q.A., Axmedov Sh.M., Shagiyazova L.M. - METABOLYTIC PROCESS IN UROLITHIASIS COMPLICATED BY OBSTRUCTIVE PYELONEPHRITIS IN THE EXPERIMENT

METABOLYTIC PROCESS IN UROLITHIASIS COMPLICATED BY OBSTRUCTIVE PYELONEPHRITIS IN THE EXPERIMENT

Dehqonov Q.A., Axmedov Sh.M., Shagiyazova L.M. - Tashkent Pediatric Medical Institute

Resume

Currently, the problem of urolithiasis and urinary tract infection in childhood, especially in hotclimates, remains in the focus of pediatric urology. Purpose of the research: To study morphofunctional disorders of cell membranes in urolithiasiscomplicated by obstructive pyelonephritis in an experiment. Material and methods: Experimental studies were carried out on 65 (5-6 months old) male rabbits ofthe "chinchilla" breed, weighing 3000-3500 g. All animals were divided into 2 groups: group 1, EOP, against the background of traditional treatment - 30 rabbits; Group 2, EOP, against the background of metabolic treatment - 35 rabbits. Results and discussion: In experimental animals, on day 15 without treatment, glomeruli plethora is observed, the epithelium of the proximal and distal tubules is flattened, and the brush border is reduced in places. In 3 months after metabolic therapy in animals, the structure is mosaic, along with destructively altered areas, they are revealed with a normal structure. In 6 months after the start of metabolic treatment, the main part of the renal tissue has a normal structure, areas with destructively altered nephron tubules are relatively less often visible, and sclerosis is almost not detected.

Key words: morphofunctional disorders of cell membranes in urolithiasis, complicated obstructive pyelonephritis, experimental studies

First page

379

Last page

386

For citation:Dehqonov Q.A., Axmedov Sh.M., Shagiyazova L.M. - METABOLYTIC PROCESS IN UROLITHIASIS COMPLICATED BY OBSTRUCTIVE PYELONEPHRITIS IN THE EXPERIMENT//New Day in Medicine 10(96)2026 379-386 https://newdayworldmedicine.com/en/new_day_medicine/10-96-2026

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