104 -8 (94) 2026 - Dexkonov K.A., Axmedov Sh.M. - CHANGES IN CELLULAR STRUCTURES OF MEMBRANES IN URILOSIS DISEASE COMPLICATED WITH OBSTRUCTIVE PYELONEPHRITIS IN EXPERIMENTAL

CHANGES IN CELLULAR STRUCTURES OF MEMBRANES IN URILOSIS DISEASE COMPLICATED WITH OBSTRUCTIVE PYELONEPHRITIS IN EXPERIMENTAL

Dexkonov K.A., Axmedov Sh.M. - Tashkent Pediatric Medical Institute

Resume

Currently, the problem of urolithiasis and urinary tract infection in childhood, especially in hot climates, remains in the focus of pediatric urology. Purpose of the research: To study morphofunctional disorders of cell membranes in urolithiasiscomplicated by obstructive pyelonephritis in experiment. Material and methods: Experimental studies were carried out on 65 (5-6 months old) male rabbits ofthe "chinchilla" breed, weighing 3000-3500 g. All animals were divided into 2 groups: group 1, EOP, against the background of traditional treatment - 30 rabbits; Group 2, EOP, against the background of metabolic treatment - 35 rabbits. Results and discussion: In experimental animals, on day 15 without treatment, glomeruli plethora is observed, the epithelium of the proximal and distal tubules is flattened, and the brush border is reduced in places. In 3 months after metabolic therapy in animals, the structure is mosaic, along with destructively altered areas, they are revealed with a normal structure. In 6 months after the start of metabolic treatment, the main part of the renal tissue has a normal structure, areas with destructively altered nephron tubules are relatively less often visible, and sclerosis is almost not detected.

Key words: morphofunctional disorders of cell membranes in urolithiasis, complicated obstructive pyelonephritis, experimental studies

First page

764

Last page

771

For citation:Dexkonov K.A., Axmedov Sh.M. - CHANGES IN CELLULAR STRUCTURES OF MEMBRANES IN URILOSIS DISEASE COMPLICATED WITH OBSTRUCTIVE PYELONEPHRITIS IN EXPERIMENTAL//New Day in Medicine 8(94)2026 764-771 https://newdayworldmedicine.com/en/new_day_medicine/8-94-2026

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