60 -10 (96) 2026 - Ulugbekova G.J. - MAKROFAGLARNING POLARIZATSIYASI (M1/M2) VA CD MARKERLARI TAHLILI VA MAKROFAGLARNING MORFOLOGIK O‘ZGARISHLARI

MAKROFAGLARNING POLARIZATSIYASI (M1/M2) VA CD MARKERLARI TAHLILI VA MAKROFAGLARNING MORFOLOGIK O‘ZGARISHLARI

Ulugbekova G.J. - Andijon davlat tibbiyot instituti

Resume

Ushbu maqolada makrofaglarning M1/M2 polarizatsiyasi, ularning funksional xususiyatlari, CD markerlari va morfologik o‘zgarishlari tahlil qilinadi. M1 makrofaglar yallig‘lanish jarayonlarida ishtirok etib, immun himoyasini ta’minlasa, M2 makrofaglar yallig‘lanishni cheklash, to‘qimalar regeneratsiyasi va tiklanishida muhim ahamiyatga ega. CD80, CD86, CD163 va CD206 kabi markerlar makrofaglarning funksional holatini baholashda muhim hisoblanadi. Shuningdek, makrofaglarning shakli, hujayra hajmi va sitoplazmatik tuzilishidagi o‘zgarishlar ularning faollik darajasi bilan bog‘liq holda ko‘rib chiqiladi. Makrofaglar polarizatsiyasini kompleks baholash yallig‘lanish va to‘qimalar tiklanishi mexanizmlarini chuqurroq tushunishga xizmat qiladi.

Kalit so‘zlar: makrofaglar, M1/M2 polarizatsiyasi, CD markerlari, morfologiya, yallig‘lanish, immun javob, to‘qima regeneratsiyasi.

First page

392

Last page

397

For citation:Ulugbekova G.J. - MAKROFAGLARNING POLARIZATSIYASI (M1/M2) VA CD MARKERLARI TAHLILI VA MAKROFAGLARNING MORFOLOGIK O‘ZGARISHLARI//New Day in Medicine 10(96)2026 392-397 https://newdayworldmedicine.com/en/new_day_medicine/10-96-2026

ADABIYOTLAR RO’YXATI

  1. Weinberg R.A. The Biology of Cancer. 2nd Edition. New York: Garland Science, 2013; 960.
  2. Louis D.N., Perry A., Wesseling P., Brat D.J., Cree I.A., Figarella-Branger D., Hawkins C., Ng H.K., Pfister S.M., Reifenberger G., Soffietti R., von Deimling A., Ellison D.W. (2021). The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-oncology, 2021;23(8):1231–1251. https://doi.org/10.1093/neuonc/noab106
  3. Qian B.Z., Pollard J.W. (2020). Macrophage diversity enhances tumor progression. Cell, 2020;182(4):689-708 https://doi.org/10.1016/j.cell.2020.07.016
  4. Murray P.J., Allen J.E., Biswas S.K., Fisher E.A., Gilroy D.W., Goerdt S., Gordon S., Hamilton J.A., Ivashkiv L.B., Lawrence T., Locati M., Mantovani A., Martinez F.O., Mege J.L., Mosser D.M., Natoli G., Saeij J.P., Schultze J.L., Shirey K.A., Sica A., … Wynn T.A. (2014). Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity, 2014;41(1): 14–20. https://doi.org/10.1016/j.immuni.2014.06.008
  5. Sica A., Mantovani A. (2022). Macrophage plasticity and polarization: In vivo veritas. Science, 2022;376(6590):1871. https://doi.org/10.1126/science.abj1871
  6. Khan S.U., Khan M.U., Azhar Ud Din M., Khan I.M., Khan M.I., Bungau S., Hassan S.S.U. (2023). Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy. Frontiers in immunology, 14, 1166487. https://doi.org/10.3389/fimmu.2023.1166487
  7. Behzadi A, Imani S, Deravi N, et al. Antiviral Potential of Melissa officinalis L.: A Literature Review [retracted in: Nutr Metab Insights. 2025 Oct 30;18:11786388251391071. doi: 10.1177/11786388251391071.]. Nutr Metab Insights. 2023;16:11786388221146683. Published 2023 Jan 12. doi:10.1177/11786388221146683
  8. Cunha LR, Muniz-Junqueira MI, Dos Santos Borges TK. Impact of polyphenols in phagocyte functions. J Inflamm Res. 2019;12:205-217. Published 2019 Aug 21. doi:10.2147/JIR.S193749
  9. Ghorbani, A., Esmaeilizadeh, M. (2017). Pharmacological properties of Salvia officinalis and its components. Journal of traditional and complementary medicine, 2017;7(4):433-440. https://doi.org/10.1016/j.jtcme.2016.12.014
  10. Weyh C, Krüger K, Peeling P, Castell L. The Role of Minerals in the Optimal Functioning of the Immune System. Nutrients. 2022;14(3):644. Published 2022 Feb 2. doi:10.3390/nu14030644

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