72 -10 (96) 2026 - Matrizayeva Q.M. - SIMPTOMSIZ BAKTERIURIYALI HOMILADORLARNING TURMUSH O'RTOQLARIDA UROGENITAL MIKROBIOTSENOZ HOLATI VA ANTIBIOTIKLARGA SEZUVCHANLIK PROFILI

SIMPTOMSIZ BAKTERIURIYALI HOMILADORLARNING TURMUSH O'RTOQLARIDA UROGENITAL MIKROBIOTSENOZ HOLATI VA ANTIBIOTIKLARGA SEZUVCHANLIK PROFILI

Matrizayeva Q.M. - Abu Ali ibn Sino nomidagi Buxoro davlat tibbiyot instituti

Resume

Maqsad: simptomsiz bakteriuriya (SB) aniqlangan homiladorlarning turmush o'rtoqlarida siydik va sperma suyuqligi mikroflorasini o'rganish hamda er va xotindan ajratilgan shtammlarning antibiotiklarga sezuvchanligini qiyosiy baholash. Material va usullar: SB aniqlangan 80 nafar homilador (45 nafari erlari bilan birga tekshirilgan) va 30 nafar sog'lom homilador hamda ularning turmush o'rtoqlari tekshirildi. Siydik va sperma suyuqligi bakteriologik ekildi, sezuvchanlik disk-diffuziya usuli va BD Phoenix M50 analizatorida aniqlandi. Natijalar: asosiy guruh erkaklarida steril siydik namunasi 4,4% (nazoratda 23,3%), steril sperma 6,7% (nazoratda 56,7%; p<0,001) holatda qayd etildi. E. coli siydikda 24,4%, spermada 22,2% uchradi, K. pneumoniae esa faqat asosiy guruhda aniqlandi. Aminoglikozidlar (75,0%) va levofloksatsin (71,25%) eng faol preparatlar bo'ldi, amoksitsillin, ko-trimoksazol va klaritromitsinga rezistentlik 62,5–80,0% ni tashkil etdi. Xulosa: jinsiy sherik urogenital trakti SB uchun reinfeksiya manbai bo'lib xizmat qiladi, shu sababli juftlikni birga tekshirish va antibiotikogramma asosida davolash maqsadga muvofiq.

Kalit so'zlar: simptomsiz bakteriuriya, homiladorlik, jinsiy sherik, sperma suyuqligi, Escherichia coli, antibiotikorezistentlik, BD Phoenix M50.

First page

457

Last page

461

For citation:Matrizayeva Q.M. - SIMPTOMSIZ BAKTERIURIYALI HOMILADORLARNING TURMUSH O'RTOQLARIDA UROGENITAL MIKROBIOTSENOZ HOLATI VA ANTIBIOTIKLARGA SEZUVCHANLIK PROFILI//New Day in Medicine 10(96)2026 457-461 https://newdayworldmedicine.com/en/new_day_medicine/10-96-2026

ADABIYOTLAR RO’YXATI

1. Abdullayeva LM, Yusupov UYu, Nadirxanova NS, Lyubchich AS. Homiladorlik davrida siydik chiqarish yo'llari infeksiyalarini tashxislash va davolash bo'yicha milliy klinik bayonnoma. Toshkent; 2021.
2. Matrizayeva QM, Yusupova MA. Asimptomatik bakteriuriya va perinatal asoratlar. Fundamental va klinik tibbiyot axborotnomasi. 2026;21(1):292–295.
3. Палагин ИС, Сухорукова МВ, Дехнич АВ, et al. Антибиотикорезистентность возбудителей внебольничных инфекций мочевых путей в России: результаты многоцентрового исследования «ДАРМИС-2018». КМАХ. 2019;21(2):134–146.
4. Boutouchent N, Vu TNA, Landraud L, Kennedy SP. Urogenital colonization and pathogenicity of E. coli in the vaginal microbiota during pregnancy. Sci Rep. 2024;14:25523. doi:10.1038/s41598-024-76438-2. Scientific Reports+1
5. Denoble A, Reid HW, Krischak M, et al. Bad bugs: antibiotic-resistant bacteriuria in pregnancy and risk of pyelonephritis. Am J Obstet Gynecol MFM. 2022;4(2).
6. de Souza HD, Diório GRM, Peres SV, et al. Bacterial profile and prevalence of urinary tract infections in pregnant women in Latin America: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2023;23:774.
7. Klein RD, Hultgren SJ. Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies. Nat Rev Microbiol. 2020;18(4):211–226.
8. Li Y, Altalbawy FMA, Hajiahmadi A, et al. Antimicrobial resistance profile and molecular analysis of virulence among Escherichia coli isolated from pregnant women with asymptomatic bacteriuria in Gorgan, Iran. BMC Pregnancy Childbirth. 2026;26:254. doi:10.1186/s12884-026-08765-3.
9. Nicolle LE, Gupta K, Bradley SF, et al. Clinical practice guideline for the management of asymptomatic bacteriuria: 2019 update by the Infectious Diseases Society of America. Clin Infect Dis. 2019;68(10):e83–e110. doi:10.1093/cid/ciy1121.
10. Mohapatra S, Venugopal SJ, Kalaivani M, et al. Antibiotic resistance of uropathogens among the community-dwelling pregnant and nonpregnant female: a step towards antibiotic stewardship. BMC Infect Dis. 2022;22:939.

    file

    download