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  • 78 -10 (96) 2026 - Ergasheva D.I., Shakirov S.A., Shokirova S.M. - YO’LDOSH QON AYLANISHI BUZILISHIDA VORSINKALI DARAXT, STROMA VA ENDOTELIYNING GESTATSION QAYTA QURILISHI: MORFOMETRIK VA IMMUNOGISTOKIMYOVIY (CD31, CD34, VEGFR, CD95) TAHLIL

78 -10 (96) 2026 - Ergasheva D.I., Shakirov S.A., Shokirova S.M. - YO’LDOSH QON AYLANISHI BUZILISHIDA VORSINKALI DARAXT, STROMA VA ENDOTELIYNING GESTATSION QAYTA QURILISHI: MORFOMETRIK VA IMMUNOGISTOKIMYOVIY (CD31, CD34, VEGFR, CD95) TAHLIL

YO’LDOSH QON AYLANISHI BUZILISHIDA VORSINKALI DARAXT, STROMA VA ENDOTELIYNING GESTATSION QAYTA QURILISHI: MORFOMETRIK VA IMMUNOGISTOKIMYOVIY (CD31, CD34, VEGFR, CD95) TAHLIL

Ergasheva D.I., Shakirov S.A. - O’zbekiston Farg'ona jamoat salomatligi tibbiyot instituti

Shokirova S.M. - Andijon davlat tibbiyot instituti

Rezyume

Homiladorlikning 11, 23 va 30 haftalarida yo’ldosh vorsinkalari, stromasi va endoteliysidagi o’zgarishlarni o’rganish hamda qon aylanishi buzilishining erta morfologik belgilarini aniqlash. 11 (n=13), 23 (n=15) va 30 (n=20) haftalik jami 48 ta yo’ldosh o’rganildi; 11-haftalik namunalar orasidan Amsterdam konsensusi mezonlari bo’yicha qon aylanishi buzilishi belgilari bo’lganlari alohida ajratildi. Namunalar G-E va Van Gizon usullarida bo’yaldi; CD31, CD34, VEGFR va CD95 immunogistokimyoviy aniqlandi. Morfometriya va ekspressiya QuPath 0.4.0 da hisoblandi, statistik tahlil Statistica dasturida bajarildi. Gestatsiya oshgani sari vorsinkalar ingichkalashdi (116,2±4,6 dan 53,8±2,4 mkm gacha), soni (43,8±2,3 dan 87,6±3,9 gacha) va kapillyarlar soni (3,5±0,3 dan 6,6±0,5 gacha) ortdi, fibrinoid 4,8% dan 14,5% ga yetdi. Qon aylanishi buzilgan 11-haftalik yo’ldoshlarda kapillyarlar ikki marta kam (1,7±0,2; p<0,001), fibrinoid 3,5 marta ko’p (16,8±1,3%; p<0,001) edi. 30-haftaga kelib barcha markerlar ekspressiyasi oshdi, eng ko’p — CD95 (28,3% dan 36,6% gacha). Kapillyar tarmoq va kollagen karkas yetilishi endoteliy apoptozining kuchayishi bilan kechadi. Erta muddatda kapillyarlar kamligi va fibrinoid ko’pligi platsentar disfunksiyadan darak berishi mumkin.

Kalit so’zlar: yo’ldosh, qon aylanishi buzilishi, morfometriya, Van Gizon, CD31, CD34, VEGFR, CD95, QuPath.

First page

496

Last page

502

For citation:Ergasheva D.I., Shakirov S.A., Shokirova S.M. - YO’LDOSH QON AYLANISHI BUZILISHIDA VORSINKALI DARAXT, STROMA VA ENDOTELIYNING GESTATSION QAYTA QURILISHI: MORFOMETRIK VA IMMUNOGISTOKIMYOVIY (CD31, CD34, VEGFR, CD95) TAHLIL//New Day in Medicine 10(96)2026 496-502 https://newdayworldmedicine.com/en/new_day_medicine/10-96-2026

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