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  • 61 -3 (41) 2022 — Khamdamov B.Z., Oblokulov A.A., — POSSIBILITIES OF STUDYING INFLAMMATORY MEDIATORS AS MARKERS OF SPONTANEOUS BACTERIAL PERITONITIS IN LIVER CIRRHOSIS OF VIRAL ETIOLOGY

61 -3 (41) 2022 — Khamdamov B.Z., Oblokulov A.A., — POSSIBILITIES OF STUDYING INFLAMMATORY MEDIATORS AS MARKERS OF SPONTANEOUS BACTERIAL PERITONITIS IN LIVER CIRRHOSIS OF VIRAL ETIOLOGY

POSSIBILITIES OF STUDYING INFLAMMATORY MEDIATORS AS MARKERS OF SPONTANEOUS BACTERIAL PERITONITIS IN LIVER CIRRHOSIS OF VIRAL ETIOLOGY

Khamdamov B.Z., Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara

Oblokulov A.A., Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara

Ismailova A.A., Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara

Adylov D.G., Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of  Uzbekistan,

Ubaidullaev S.A., Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of  Uzbekistan,

Alimova D.B. Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of  Uzbekistan,

Resume

Purpose of the study. To assess the body’s immunoreactivity by studying the main inflammatory mediators as a criterion for spontaneous bacterial peritonitis in liver cirrhosis of viral etiology.

Material and research methods. 64 hospitalized patients with confirmed decompensated liver cirrhosis (38 men and 26 women) were examined. All patients were divided into 2 groups: persons with cirrhosis with SBP and persons with cirrhosis without SBP. Immunological studies were carried out by ELISA.

Results and its discussion. Serum concentrations of the main pro-inflammatory cytokines were studied in decompensated cirrhosis with spontaneous bacterial peritonitis and liver cirrhosis without peritonitis.

Findings: 1. Elevated serum levels of IL-1β were found in patients with cirrhosis with SBP, 11 times higher than normal, and 2.4 times higher than the values ​​of patients with cirrhosis without peritonitis. The level of IL-1β can serve as a marker for early diagnosis and prognosis of bacterial peritonitis against the background of ascitic cirrhosis.

2. The content of IL-6 in the blood serum in patients with cirrhosis with SBP was significantly increased, and the level of IL-6 in the group of persons with cirrhosis with SBP was increased by 6.3 times compared with the control, and in the group of patients with cirrhosis without SBP – by 2 .7 times, respectively. Between groups, IL-6 values ​​were 2.3 times higher in cirrhosis with SBP.

3. The concentration of IL-8 in patients with cirrhosis with SBP was significantly increased in patients with cirrhosis with SBP by 7 times compared with the control, in the group of patients with cirrhosis without SBP – by 3.4 times, respectively, and among themselves.

Key words: main immune cytokines, interleukins, immunity, liver cirrhosis, bacterial peritonitis, viral hepatitis.

First page

289

Last page

296

For citation: Khamdamov B.Z., Oblokulov A.A., Ismailova A.A., Adylov D.G., Ubaidullaev S.A., Alimova D.B. POSSIBILITIES OF STUDYING INFLAMMATORY MEDIATORS AS MARKERS OF SPONTANEOUS BACTERIAL PERITONITIS IN LIVER CIRRHOSIS OF VIRAL ETIOLOGY //New Day in Medicine 3(41)2022 289-296 https://clck.ru/gMLEo

LIST OF REFERENCES:

  1. Астахин А.В. Система регуляторных цитокинов и сывороточного интерферона альфа при хронических диффузных заболеваниях печени. /Автореферат дисс. д.м.н. 2004, 24с.
  2. Балашова А.А., Аришева О.С., Гармаш И.В. и соавт. Цитокины и алкогольная болезнь печени. // – Клинич.фармак. и терапия – 2017 – Т. 26 (1) – с. 41-45.
  3. Булатова И.А., Щекотова А.Б., Подучаева С.Б. и др. Цитокины у больных циррозом печени вирусного и невирусного генеза. // Новости «Вектор – Вест» – 2015- №1 (75) – С.2 – 5.
  4. Ивашкин В.Т., Маевская М.В., Павлов Ч.С. и соавт. Клинические рекомендации Российского общества по изучению печени по ведению взрослых пациентов с алкогольной болезнью печени. // Росс.Журн.Гастр.Гепат. и Колопр. – 2017 – Т. 27. – №6 – с. 20-40.
  5. Холматов П.К., Додхоев Д.С., Хидиров М.А. Концентрация интерлейкина-6 в сыворотке крови больных циррозом печени. //Вестник Авиценны – 2013. – №2 (55) – С. 149-152.
  6. Abdel-Rahman N Zekri., Hanaa M Alam El-Din et all. Serum levels of soluble Fas, Soluble TNF-receptor-II, interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus Genotype-4. // Comp. Hepatolog. – 2010. – №9 (1)
  7. Buch A.C., Patil A., Haldar N et all. Relation of Lymfocyte subsets and cytokines in different grades of alcoholic cirrhosis. // J. of clinical and clin. – 2019 – Vol. 13(1). – P. 8-11.
  8. Claria J., Stauber RE., Coenraad M J et al. Sistemic inflammation in decompensated cirrhosis: Characterization and role in acute – on chronic liver failure // Hepatology – 2016. – № 64 (4) – P. 1249 – 1262
  9. Claudia O., Zein., Rocio Lopes., Xiaoming Fu. Pentoxifylline decreases oxidized linid products et all in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism. // J. Hepatology. – 2012. -№56. – P. 1291-1299.
  10. Dirchwolf M., Podhorzer A., Marino M et al. Immune dysfunction in cirrhosis: Distinet cytokines phenotypes according to cirrhosis severity. // CytoKine . – 2016. – №77. – P. 14-25.
  11. Fathia A Manaa., Khaled G., Abdel Wahhab. Physiological potential of cytokines and liver damages. // Hepatoma Res. – 2016 – №2 – P. 131-143.
  12. Fisher J., Silva T.E., Soares E Silva et al. From stable disease to acuteon-chronic liver failure: circulating cytokines are related prognosis in different states of cirrhosis. // Cytokines – 2017. – №91 – P. 162-169.
  13. Iiangumaran S., Morrigl R., Kalvakolanu DV. Editoriali Cytokines in liver diseases. // Cytokine – 2019 – Vol. 124 – P.54
  14. Joan Claria., Vicente Arroyo., Richard Morean. The acute – on -chronic liver failure syndrom, or when the innate immune system gaes astray. // J. of Immunology – 2016 – T. 197. Vol.10. P.3755-3761.
  15. Josiane Fisher., Leonardo Lucca Schiavon. From stable disease to acute-on chronic liver failure: circulation cytokines are related to prognosis in different stages of cirrhosis. // Cytokine – 2017 – Vol. 91 – P. 162-169.
  16. Koyama Y., Xu J., Liu X et al. New developments on the treatment of liver fibrosis. // Di.dis. – 2016 – Vol. 34 – №5 – P.589-596.
  17. Lebrec D., Thabut D., Oberti F et al. Pentoxifilline does not decrease shot-term mortality but does reduce complications in patients with advanced cirrhosis // Gastroenterology – 2010. – №138 (5) – P. 1755-1762.
  18. Manuel Romero-Gomez., Rajiv Jalan. Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure // J. of Hepatology – 2015. – V.62. P. 437-447.
  19. Manzhalii E., Virchenko O., Falalycyeva T et al. Hepatic encephalopathy aggravated by systemic inflammation. // Dig. thy gys – 2019 – V.37 – №6. – P. 509-517.
  20. Martin-Mateos., Melchor Alvares., Mon M., Albillos A., Dysfunctional immune response in Acute – on – chronic liver failure: in takes two to tango. // Fronties in immunology – 2019 – №10 – P. 973-992.

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