88 -3 (89) 2026 - Sunyoung Woo, Mun A.V. - THE ROLE OF SKIN MICROBIOTA IN ATOPIC DERMATITIS IN CHILDREN

THE ROLE OF SKIN MICROBIOTA IN ATOPIC DERMATITIS IN CHILDREN

Sunyoung Woo - Tashkent State Medical University

Mun A.V. - Tashkent State Medical University

Resume

Pediatric atopic dermatitis (AD) is a chronic, relapsing, and pruritic inflammatory skin disorder with high prevalence worldwide. It is characterized by epidermal barrier defects, immune dysregulation, and heightened sensitivity to environmental stimuli. AD in children often initiates the “atopic march,” predisposing them to food allergies, asthma, and allergic rhinitis. The hallmark symptom, pruritus, triggers an itch-scratch cycle that exacerbates barrier dysfunction and facilitates microbial colonization. The skin microbiota plays a critical role in disease pathogenesis; dysbiosis, marked by reduced microbial diversity and overgrowth of Staphylococcus aureus, correlates with disease severity. Commensal organisms such as Staphylococcus epidermidis contribute to barrier protection but may act variably depending on strain and disease stage. Bacteriophages targeting pathogenic bacteria are emerging as potential therapeutics. Lesion morphology differs by disease stage, with acute lesions showing erythema, edema, and vesiculation, whereas chronic lesions demonstrate lichenification and xerosis. Age-specific lesion distribution informs sampling and treatment strategies. Secondary infections, barrier dysfunction, and flare triggers further complicate management. Topical corticosteroids, calcineurin inhibitors, and emollients are central to therapy, reducing inflammation, restoring barrier integrity, and normalizing microbiota. Standardized scoring systems, such as SCORAD and EASI, correlate disease severity with microbial imbalance. Understanding the interplay between skin microbiota, host immunity, and barrier function is essential for improving therapeutic outcomes and developing targeted interventions in pediatric AD.

Keywords: Atopic dermatitis, Children, Bacteriophages, Dysbiosis, Staphylococcus aureus

First page

541

Last page

546

For citation:Sunyoung Woo, Mun A.V. - THE ROLE OF SKIN MICROBIOTA IN ATOPIC DERMATITIS IN CHILDREN//New Day in Medicine 3(89)2026 541-546 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

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