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  • 89 -3 (89) 2026 - Makhmatkulov S.M., Mavlyanova Z.F. - A COMPREHENSIVE APPROACH TO THE REHABILITATION OF WOMEN WITH URINARY INCONTINENCE DUE TO TYPE 2 DIABETES MELLITUS

89 -3 (89) 2026 - Makhmatkulov S.M., Mavlyanova Z.F. - A COMPREHENSIVE APPROACH TO THE REHABILITATION OF WOMEN WITH URINARY INCONTINENCE DUE TO TYPE 2 DIABETES MELLITUS

A COMPREHENSIVE APPROACH TO THE REHABILITATION OF WOMEN WITH URINARY INCONTINENCE DUE TO TYPE 2 DIABETES MELLITUS

Makhmatkulov S.M. - Samarkand State Medical University

Mavlyanova Z.F. - Samarkand State Medical University

Mavlyanov S.F. - Samarkand State Medical University

Ashurov R.F. - Samarkand State Medical University

Resume

Purpose of the study. To evaluate the clinical efficacy and safety of a combined rehabilitation program including intravesical administration of botulinum toxin type A followed by a course of percutaneous tibial neuromodulation in women with urge urinary incontinence associated with type 2 diabetes mellitus. Material and methods. The study included 122 women with urgency urinary incontinence (URI) meeting the criteria for overactive bladder and associated with type 2 diabetes. The study group consisted of 62 patients who received intravesical botulinum toxin therapy at a dose of 300 U combined with a course of percutaneous tibial neuromodulation. The comparison group included 60 patients who received standard conservative therapy. Three-day voiding diary data, ICIQ-SF and OAB-q questionnaire scores, urinary NGF/Cr levels, pelvic floor muscle ENMG parameters, and residual urine volume were assessed. Results. After 12 weeks, the main group showed a more pronounced improvement compared to the comparison group.. The average number of episodes of urgent urinary incontinence decreased from 5.8 ± 1.4 to 1.4 ± 0.8 per day versus a decrease from 5.7 ± 1.3 to 3.9 ± 1.2 in the comparison group. The ICIQ-SF score decreased from 16.3 ± 2.0 to 5.1 ± 1.5 points versus 16.1 ± 2.1 to 11.7 ± 2.0, the OAB-q symptom severity score decreased from 67.9 ± 7.3 to 27.1 ± 6.0 points versus 68.1 ± 7.0 to 49.8 ± 7.0. A significant subjective improvement was recorded in 54 of 62 patients in the main group (87.1%) and in 24 of 60 patients in the comparison group (40.0%). The NGF/Cr level decreased from 42.5 ± 10.2 to 18.7 ± 6.7 pg/mg creatinine in the main group and from 41.8 ± 9.8 to 31.4 ± 8.2 pg/mg creatinine in the comparison group. Conclusion. A combined program using intravesical botulinum toxin therapy and subsequent percutaneous tibial neuromodulation demonstrated high clinical efficacy and was superior to standard conservative therapy in most clinical and functional indicators.

Keywords: Urgent urinary incontinence, overactive bladder, type 2 diabetes mellitus, botulinum therapy, PTNS, NGF, rehabilitation.

First page

547

Last page

552

For citation:Makhmatkulov S.M., Mavlyanova Z.F., Mavlyanov S.F., Ashurov R.F. - A COMPREHENSIVE APPROACH TO THE REHABILITATION OF WOMEN WITH URINARY INCONTINENCE DUE TO TYPE 2 DIABETES MELLITUS//New Day in Medicine 3(89)2026 547-552 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

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