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  • 94 -3 (89) 2026 - Bakamov D.U., Tosheva Kh.B. - EFFICACY OF HORMONE REPLACEMENT THERAPY IN THE TREATMENT OF PEPTIC ULCER DISEASE IN FERTILE AND POSTMENOPAUSAL WOMEN

94 -3 (89) 2026 - Bakamov D.U., Tosheva Kh.B. - EFFICACY OF HORMONE REPLACEMENT THERAPY IN THE TREATMENT OF PEPTIC ULCER DISEASE IN FERTILE AND POSTMENOPAUSAL WOMEN

EFFICACY OF HORMONE REPLACEMENT THERAPY IN THE TREATMENT OF PEPTIC ULCER DISEASE IN FERTILE AND POSTMENOPAUSAL WOMEN

Bakamov D.U. - Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Tosheva Kh.B. - Bukhara State Medical Institute named after Abu Ali Ibn Sina

Resume

This article evaluates the efficacy of hormone replacement therapy (HRT) added to standard H. pylori eradication for treating peptic ulcer disease (PUD) in postmenopausal women. 120 women were enrolled: fertile (n=53) and postmenopausal (n=67), subdivided into Group 2a (eradication, n=34) and 2b (eradication+HRT, n=33). Pain syndrome predominated in fertile women (98%), while dyspeptic complaints were characteristic of postmenopausal patients (p<0.001). Estradiol was 32.7±1.24 pg/mL in postmenopause — six-fold lower (p<0.001). Combined therapy raised estradiol to 92.4±3.5 pg/mL (p<0.001) with significant improvement in clinical, cognitive and autonomic parameters. Results justify mandatory inclusion of HRT in PUD treatment protocols for postmenopausal women.

Keywords: peptic ulcer disease, postmenopause, estrogen deficiency, hormone replacement therapy, H. pylori eradication, estradiol, quality of life.

First page

577

Last page

584

For citation:Bakamov D.U., Tosheva Kh.B. - EFFICACY OF HORMONE REPLACEMENT THERAPY IN THE TREATMENT OF PEPTIC ULCER DISEASE IN FERTILE AND POSTMENOPAUSAL WOMEN//New Day in Medicine 3(89)2026 577-584 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

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