95 -3 (89) 2026 - Saifutdinova Z., Yarmukhamedov A. - INFERTILITY FEATURES ASSOCIATED WITH AZF MICRODELETIONS AND HORMONE PROFILES

INFERTILITY FEATURES ASSOCIATED WITH AZF MICRODELETIONS AND HORMONE PROFILES

Saifutdinova Z. - Tashkent State Medical University

Yarmukhamedov A. - Tashkent State Medical University

Sarsenbaeva U. - Tashkent State Medical University

Soxibova G. - Tashkent State Medical University

Resume

This study aimed to investigate AZF microdeletions and hormonal profiles in 380 men presenting with infertility. Patients were classified into AZF-positive (AZF+) and AZF-negative (AZF–) groups, with AZF+ patients showing AZFa, AZFb, and isolated AZFc deletions. Based on hormonal profiling, five groups were identified: hypergonadotropic hypogonadism (GiperG), normogonadotropic hypogonadism (NormoG), normogonadotropic eugonadism (NormoE), hypergonadotropic eugonadism (GiperE), and hypogonadotropic hypogonadism (GipoG). Results demonstrated that AZF microdeletions are associated with male infertility, while hormonal profiles are essential for evaluating spermatogenesis. A history of epidemic parotitis was associated with increased infertility risk in the AZF– group.

Keywords: AZF microdeletions, male infertility, hormonal profile, FSH, LH, testosterone, spermatogenesis

First page

585

Last page

590

For citation:Saifutdinova Z., Yarmukhamedov A., Sarsenbaeva U., Soxibova G. - INFERTILITY FEATURES ASSOCIATED WITH AZF MICRODELETIONS AND HORMONE PROFILES//New Day in Medicine 3(89)2026 585-590 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

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