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  • 96 -3 (89) 2026 - Yarmukhamedov A., Saifutdinova Z. - MOLECULAR-GENETIC AND CLINICAL FEATURES OF MALE INFERTILITY: AZF MICRODELETIONS, CFTR MUTATIONS, AND ENHANCED RISK FACTORS

96 -3 (89) 2026 - Yarmukhamedov A., Saifutdinova Z. - MOLECULAR-GENETIC AND CLINICAL FEATURES OF MALE INFERTILITY: AZF MICRODELETIONS, CFTR MUTATIONS, AND ENHANCED RISK FACTORS

MOLECULAR-GENETIC AND CLINICAL FEATURES OF MALE INFERTILITY: AZF MICRODELETIONS, CFTR MUTATIONS, AND ENHANCED RISK FACTORS

Yarmukhamedov A. - Tashkent State Medical University

Saifutdinova Z. - Tashkent State Medical University

Shomansurova G. - Tashkent State Medical University

Resume

The study analyzed Y-chromosome AZF microdeletions, CFTR gene mutations, semen parameters, and acquired risk factors in different hormonal forms of male infertility. The results demonstrated that AZFa and AZFb microdeletions are primarily associated with hypergonadotropic hypogonadism, AZFc deletions show phenotypic variability, and the CFTR_F508del mutation is detected in normogonadotropic eugonadism. Additionally, paternal age and smoking may play a potential etiological role in the occurrence of AZF microdeletions.

Keywords: Male infertility, AZF microdeletions, CFTR mutations, semen analysis, hormonal profile, risk factors

First page

591

Last page

596

For citation:Yarmukhamedov A., Saifutdinova Z., Shomansurova G. - MOLECULAR-GENETIC AND CLINICAL FEATURES OF MALE INFERTILITY: AZF MICRODELETIONS, CFTR MUTATIONS, AND ENHANCED RISK FACTORS//New Day in Medicine 3(89)2026 591-596 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

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