2 -4 (90) 2026 - S.A.Begmanov, Z.S.Shahabutdinov - MORPHO-METABOLICAL CHANGES OBSERVED DURING THE TREATMENT OF EXPERIMENTAL HEPATITIS AND ULCERATIVE COLITIS WITH MUMIYA

MORPHO-METABOLICAL CHANGES OBSERVED DURING THE TREATMENT OF EXPERIMENTAL HEPATITIS AND ULCERATIVE COLITIS WITH MUMIYA

S.A.Begmanov - Tashkent State Medical University

Z.S.Shahabutdinov - Tashkent State Medical University

Resume

The aim of the study is to study morpho-functional changes in primary and secondary liver damage, regenerative processes induced by mumiya. Methods. The experiments were conducted on 229 white rats weighing 140-180 g, which were fed a standard laboratory diet. Toxic liver damage was caused by subcutaneous administration of 0.12 ml of CCl4 per 100 g of body weight daily for 25 days; ulcerative colitis of the colon was caused by oral administration of the product of biogenic amine metabolism of phenol at a dose of 3 mg per 100 g of body weight for 120 days. After the cessation of CCl4 and phenol poisoning, mumiyo was administered daily for 30-35 days at doses of 5, 15, 30 and 50 mg per 100 g of body weight. Results. With toxic liver damage, CCl4, mumiyo led to an improvement in the glycogen and protein-forming functions of the liver. Under such conditions, the restorative effect of mummy is manifested in a unilateral increase in mitochondrial conjugation without normalizing the respiratory rate. Conclusion. Our studies, confirmed by biochemical data, show that the properties of mummy as a regeneration stimulator are clearly manifested in the treatment of secondary hepatitis resulting from ulcerative lesions of the colon.

Keywords: mummy, carbon tetrachloride, phenol, hepatocyte, β-lipoprotein, glycogen, total and residual nitrogen, secondary hepatitis.

First page

12

Last page

16

For citation:S.A.Begmanov, Z.S.Shahabutdinov - MORPHO-METABOLICAL CHANGES OBSERVED DURING THE TREATMENT OF EXPERIMENTAL HEPATITIS AND ULCERATIVE COLITIS WITH MUMIYA//New Day in Medicine 4(90)2026 12-16 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

List of References

1. Стефанов А.В. Доклинические испытания лекарственных средств: методические рекомендации. Киев: Авиценна; 2002. 568 с.
2. Штробля А.Л., и др. Изучение гепатозащитных свойств сухого экстракта из листьев абрикоса обыкновенного на модели поражения печени тетрахлорметаном. Вестник РАМН. 2013;(3):68–72.
3. Большая российская энциклопедия. Т. 21. М.; 2013. 432 с.
4. Мухаммадиева Г.Ф. Анализ изменения экспрессии генов Casp7 и Chek1 при токсическом поражении печени, индуцированном тетрахлорметаном, на фоне гепатопротекторов. Гигиена и санитария. 2019;98(9):1011–1024.
5. Кулебина Е.А. Совершенствование неинвазивной диагностики фиброза при хронических болезнях печени у детей [диссертация]. Москва; 2021. 144 с.
6. Савиных М.И. Всё о мумие: материалы и результаты. Новокузнецк: Кузнецкая крепость; 1999. 81 с.
7. Усольцева О.В., и др. Связь воспалительных заболеваний кишечника с выраженностью поражения печени при аутоиммунной гепатобилиарной патологии: одномоментное исследование. Вопросы современной педиатрии. 2022;21(2):105–112.
8. Schepetkin I, Khlebnikov A, Kwon BS. Medical drugs from humus matter: focus on mumie. Drug Dev Res. 2002;57(3):140–159.

   file

   download