4 -4 (90) 2026 - Аkhtamоv Аzizbek, Radjabov Akhtam - CHANGES IN THE MORPHOLOGICAL AND MORPHOMETRIC PARAMETERS OF THE PANCREAS IN 3-MONTH-OLD RATS UNDER CONDITIONS OF EXPERIMENTAL NICOTINE INTOXICATION

CHANGES IN THE MORPHOLOGICAL AND MORPHOMETRIC PARAMETERS OF THE PANCREAS IN 3-MONTH-OLD RATS UNDER CONDITIONS OF EXPERIMENTAL NICOTINE INTOXICATION

Аkhtamоv Аzizbek - Bukhara State Medical Institute named after Abu Ali ibn Sina

Radjabov Akhtam - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The article analyzes the morphological and morphometric changes in the pancreas of three-month-old white rats under nicotine exposure in experimental conditions. Nicotine intoxication exerts a cytotoxic effect on the islets of Langerhans and acinar cells. Morphometric analysis revealed a significant decrease in the relative area of the endocrine component, the number of islets, islet area, and the number of endocrinocytes compared to the control group. In addition, a reduction in the area of endocrinocytes and cellular density was observed. The obtained data indicate that, under the influence of nicotine, the functional activity of the pancreas declines, accompanied by morphological damage associated with impaired microcirculation. These results may serve as a basis for assessing toxic effects and for conducting preventive studies using morphometric analysis.

Keywords: pancreas, nicotine, morphometry, acinar cells, Langerhans islets.

First page

26

Last page

30

For citation:Аkhtamоv Аzizbek, Radjabov Akhtam - CHANGES IN THE MORPHOLOGICAL AND MORPHOMETRIC PARAMETERS OF THE PANCREAS IN 3-MONTH-OLD RATS UNDER CONDITIONS OF EXPERIMENTAL NICOTINE INTOXICATION//New Day in Medicine 4(90)2026 26-30 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

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