9 -4 (90) 2026 - Kosimov A.L., Sadikov R.A. - MORPHOLOGICAL CHARACTERISTICS OF THE SKIN AND SUBCUTANEOUS PELLICLE IN EXPERIMENTAL CARBULCUS AGAINST THE BACKGROUND OF DIABETES MELLITUS AND VARIOUS METHODS OF SURGICAL TREATM

MORPHOLOGICAL CHARACTERISTICS OF THE SKIN AND SUBCUTANEOUS PELLICLE IN EXPERIMENTAL CARBULCUS AGAINST THE BACKGROUND OF DIABETES MELLITUS AND VARIOUS METHODS OF SURGICAL TREATMENT

Kosimov A.L. - Andijan State Medical Institute, State Institution "Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov". Uzbekistan

Sadikov R.A. - Andijan State Medical Institute, State Institution "Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov". Uzbekistan

Komilzhonov A.E. - Andijan State Medical Institute, State Institution "Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov". Uzbekistan

Mardonov J.N. - Andijan State Medical Institute, State Institution "Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov". Uzbekistan

Resume

The scientific article presents morphological changes in the skin and subcutaneous tissue under the conditions of an experimental carbuncle on a model of diabetes mellitus (DM) and the effects of various surgical treatment methods. The experimental studies were conducted at the laboratory of the Vakhidov Russian Scientific and Practical Center for Surgery between 2024 and 2025. The authors describe in detail the methodology for modeling DM and the formation of a carbuncle in the neck region in laboratory rats. The results of the study show that the use of the laser method of surgical treatment in combination with a combined gel composition provides rapid wound cleansing from necrotic tissues, early restoration of microcirculation, formation of granulation tissue and acceleration of epithelization.

Keywords: modeling of DM, carbuncle, morphological features of the skin and subcutaneous tissue, laser exposure, microcirculation, epithelization, granulation.

First page

58

Last page

68

For citation:Kosimov A.L., Sadikov R.A., Komilzhonov A.E., Mardonov J.N. - MORPHOLOGICAL CHARACTERISTICS OF THE SKIN AND SUBCUTANEOUS PELLICLE IN EXPERIMENTAL CARBULCUS AGAINST THE BACKGROUND OF DIABETES MELLITUS AND VARIOUS METHODS OF SURGICAL TREATMENT//New Day in Medicine 4(90)2026 58-68 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026

List of References

1. Ёдгорова НТ, Махмудов ССУ, Тошпулатова ЛУК. Общая характеристика больных сахарным диабетом с осложненными гнойно-воспалительными заболеваниями. Биология и интегративная медицина. 2016;(6).
2. Липатов КВ, Фархат ФА, Фомин НН, Лапин РВ, Бычков СВ. Особенности хирургической тактики при лечении больных с карбункулами. Альманах клинической медицины. 2006;(11). Available from: https://cyberleninka.ru/article/n/osobennosti-hirurgicheskoy-taktiki-pri-lechenii-bolnyh-s-karbunkulami
3. Норчаев Ж. Особенности течения и ведения больных с гнойно-воспалительными заболеваниями мягких тканей головы и шеи на фоне сахарного диабета. Медицина и инновации. 2022;1(4):258–264.
4. Охунов АО, Бабаджанов БД, Пулатов УИ. Причины генерализации инфекции у больных с гнойно-воспалительными заболеваниями мягких тканей на фоне сахарного диабета. Вестник Ташкентской медицинской академии. 2016;(4):89–93.
5. Очилов У. Клиническое течение раневого процесса у больных с гнойными хирургическими заболеваниями мягких тканей на фоне диффузного токсического зоба и сахарного диабета в сочетании. Инновационные исследования в современном мире: теория и практика. 2024;(3,9):72–75.
6. Chen L, Zhang S, Da J, et al. A systematic review and meta-analysis of efficacy and safety of negative pressure wound therapy in the treatment of diabetic foot ulcer. Ann Palliat Med. 2021;10(10):10830–10839. doi:10.21037/apm-21-2476
7. David P, Singh S, Ankar R. A comprehensive overview of skin complications in diabetes and their prevention. Cureus. 2023;15(5):e38961. doi:10.7759/cureus.38961
8. Dawi J, Tumanyan K, Tomas K, et al. Diabetic foot ulcers: pathophysiology, immune dysregulation, and emerging therapeutic strategies. Biomedicines. 2025;13(5):1076. doi:10.3390/biomedicines13051076
9. Deng YX, Wang XC, Xia ZY, Wan MY, Jiang DY. Efficacy and safety of negative pressure wound therapy for the treatment of diabetic foot ulcers: a meta-analysis. World J Diabetes. 2025;16(6):103520. doi:10.4239/wjd.v16.i6.103520
10. Nagendra L, Boro H, Mannar V. Bacterial infections in diabetes. In: Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. Updated 2022 Apr 5. Available from: https://www.ncbi.nlm.nih.gov/books/NBK579762/

    file

    download