11 -4 (90) 2026 - Jarilkasinova G.J., Boboyorova D.N. - THE ROLE OF HELICOBACTER PYLORI INFECTION, VITAMIN B12 DEFICIENCY, AND HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF ARTERIAL HYPERTENSION
THE ROLE OF HELICOBACTER PYLORI INFECTION, VITAMIN B12 DEFICIENCY, AND HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF ARTERIAL HYPERTENSION
Jarilkasinova G.J. - Bukhara State Medical Institute named after Abu Ali ibn Sina
Boboyorova D.N. - Bukhara State Medical Institute named after Abu Ali ibn Sina
Resume
Arterial hypertension (AH) remains one of the leading causes of cardiovascular morbidity and mortality worldwide. In recent years, increasing attention has been paid to the role of chronic inflammation and metabolic disturbances in its pathogenesis. Helicobacter pylori infection is considered a potential systemic factor that may affect vascular function through the development of vitamin B12 deficiency and subsequent hyperhomocysteinemia.
Keywords: Helicobacter pylori, arterial hypertension, vitamin B12, homocysteine, endothelial dysfunction
First page
73
Last page
77
For citation:Jarilkasinova G.J., Boboyorova D.N. - THE ROLE OF HELICOBACTER PYLORI INFECTION, VITAMIN B12 DEFICIENCY, AND HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF ARTERIAL HYPERTENSION//New Day in Medicine 4(90)2026 73-77 https://newdayworldmedicine.com/en/new_day_medicine/4-90-2026
List of References
- Graham DY. Helicobacter pylori update: gastric cancer, reliable therapy, and possible extragastric manifestations. Clin Gastroenterol Hepatol. 2015;13(8):1385–1391. doi:10.1016/j.cgh.2015.03.014
- Huang B, Zhang Q, Li S, et al. Association between Helicobacter pylori infection and hypertension: a meta-analysis. Helicobacter. 2020;25(1):e12672. doi:10.1111/hel.12672
- Zhang Y, Chen X, Liu W, et al. Helicobacter pylori infection and risk of hypertension: a systematic review. J Clin Hypertens. 2021;23(4):876–883. doi:10.1111/jch.14182
- Chen L, Blaser MJ. Association between H. pylori and systemic diseases. Gut Microbes. 2022;14(1):201–210. doi:10.1080/19490976.2021.1970910
- Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality. BMJ. 2002;325:1202. doi:10.1136/bmj.325.7374.1202
- Humphrey LL, Fu R, Rogers K, Freeman M, Helfand M. Homocysteine level and coronary heart disease incidence. Mayo Clin Proc. 2008;83(11):1203–1212. doi:10.4065/83.11.1203
- Ueland PM, Refsum H, Beresford SA, Vollset SE. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr. 2000;72(2):324–332. doi:10.1093/ajcn/72.2.324
- O’Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299–316. doi:10.3390/nu2030299
- Andrès E, Serraj K, Federici L, Vogel T, Kaltenbach G. Update of nutrient-deficiency anemia in the elderly. Eur J Intern Med. 2004;15(3):165–172. doi:10.1016/j.ejim.2004.01.004
- Stabler SP. Vitamin B12 deficiency. N Engl J Med. 2013;368:149–160. doi:10.1056/NEJMra1113996
file
download