18 -5 (91) 2026 - Akbarova O.R. - PATHOMORPHOLOGY OF THE ADRENAL GLANDS IN NEWBORNS WHO DIED AS A RESULT OF BIRTH-RELATED BRAIN INJURY

PATHOMORPHOLOGY OF THE ADRENAL GLANDS IN NEWBORNS WHO DIED AS A RESULT OF BIRTH-RELATED BRAIN INJURY

Akbarova O.R. - Andijan State Medical Institute

Resume

Characteristic morphofunctional changes in the adrenal glands were identified at different severities of birth-related brain injury as a stress response. The study results demonstrated increased cortisol secretion by spongiocytes of the zona fasciculata of the adrenal cortex associated with activation of the hypothalamic-pituitary-adrenal axis. Morphologically, dystrophic and necrobiotic changes in the cells of both the cortical and medullary layers, capillary congestion, diapedetic hemorrhages, and stromal edema were observed. These alterations were particularly pronounced in severe brain injuries and may contribute to the development of adrenal functional insufficiency. The obtained findings indicate a close relationship between morphological changes in the adrenal glands, the severity of birth trauma, and the adaptive stress-response capabilities of the organism.

Keywords: adrenal glands, morphology, birth-related brain injury, necrosis, dystrophy.

First page

109

Last page

114

For citation:Akbarova O.R. - PATHOMORPHOLOGY OF THE ADRENAL GLANDS IN NEWBORNS WHO DIED AS A RESULT OF BIRTH-RELATED BRAIN INJURY//New Day in Medicine 5(91)2026 109-114 https://newdayworldmedicine.com/en/new_day_medicine/5-91-2026

List of References

  1. Moszczyńska E, Kunecka K, Baszyńska-Wilk M, Perek-Polnik M, Majak D, Grajkowska W. Pituitary stalk thickening: causes and consequences. The Children's Memorial Health Institute experience and literature review. Front Endocrinol (Lausanne). 2022;13:868558. doi:10.3389/fendo.2022.868558.
  2. Mendonça F, Ferreira AB, Pinto F, Vasconcelos A, Ferreira S, Rodrigues E, Castro-Correia C, Gil-da-Costa MJ, Bom-Sucesso M. Adrenal carcinoma as the first manifestation of a Li-Fraumeni syndrome in three paediatric patients. Endokrynol Pol. 2022;73(4):788-789. doi:10.5603/EP.a2022.0046.
  3. Nanba AT, Nanba K, Byrd JB, Shields JJ, Giordano TJ, Miller BS, Rainey WE, Auchus RJ, Turcu AF. Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism. Clin Endocrinol (Oxf). 2017;87(6):665-672. doi:10.1111/cen.13429.
  4. Prete A, Taylor AE, Bancos I, Smith DJ, Foster MA, Kohler S, et al. Prevention of adrenal crisis: cortisol responses to major stress compared to stress dose hydrocortisone delivery. J Clin Endocrinol Metab. 2020;105(7):2262-2274. doi:10.1210/clinem/dgaa133.
  5. Sakoda A, Mushtaq I, Levitt G, Sebire NJ. Clinical and histopathological features of adrenocortical neoplasms in children: retrospective review from a single specialist center. J Pediatr Surg. 2014;49(3):410-415. doi:10.1016/j.jpedsurg.2013.11.051.
  6. Sandru F, Dumitrascu MC, Petca A, Carsote M, Petca RC, Oproiu AM, Ghemigian A. Adrenal ganglioneuroma: prognostic factors (review). Exp Ther Med. 2021;22(5):1338. doi:10.3892/etm.2021.10786.
  7. Shapiro-Mendoza CK, Tomashek KM, Anderson RN, Wingo J. Recent national trends in sudden, unexpected infant deaths: more evidence supporting a change in classification or reporting. Am J Epidemiol. 2006;163(8):762-769. doi:10.1093/aje/kwj115.
  8. Sharrack N, Baxter CT, Paddock M, Uchegbu E. Adrenal haemorrhage as a complication of COVID-19 infection. BMJ Case Rep. 2020;13(11):e239643. doi:10.1136/bcr-2020-239643.
  9. Sisto JM, Liu FW, Geffner ME, Berman ML. Para-ovarian adrenal rest tumors: gynecologic manifestations of untreated congenital adrenal hyperplasia. Gynecol Endocrinol. 2018;34(8):644-646. doi:10.1080/09513590.2018.1427710.
  10. Stratakis CA. Cushing's disease in children: unique features and update on genetics. Pituitary. 2022;25(5):764-767. doi:10.1007/s11102-022-01249-0.

    file

    download