23 -5 (91) 2026 - Mamajonova Z.Sh., Egamberdiyeva D.A. - INFLAMMATORY AND METABOLIC DETERMINANTS OF CORONARY CALCIFICATION IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE

INFLAMMATORY AND METABOLIC DETERMINANTS OF CORONARY CALCIFICATION IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE

Mamajonova Z.Sh. - Tashkent State Medical University

Egamberdiyeva D.A. - Tashkent State Medical University

Resume

The aim of the study was to assess the relationship between inflammatory-metabolic factors and the severity of coronary artery calcification in patients with chronic ischemic heart disease (IHD). A total of 135 patients with chronic IHD were included. All participants underwent clinical assessment, body mass index (BMI) evaluation, measurement of inflammatory biomarkers (IL-6, hs-CRP, fibrinogen), insulin resistance index (HOMA-IR), and coronary artery calcium (CAC) scoring. Increasing BMI was associated with a higher prevalence of arterial hypertension, hyperlipidemia, diabetes mellitus, and clinically significant coronary calcification. Elevated IL-6, hs-CRP, and HOMA-IR levels were significantly associated with CAC ≥100. An integrative model combining clinical, inflammatory, and metabolic parameters demonstrated high predictive value for severe coronary calcification (AUC = 0.948; p < 0.001). The findings highlight the important contribution of inflammatory and metabolic mechanisms to calcifying atherosclerosis in patients with chronic IHD.

Keywords: ischemic heart disease, coronary artery calcification, inflammation, insulin resistance, obesity.

First page

137

Last page

143

For citation:Mamajonova Z.Sh., Egamberdiyeva D.A. - INFLAMMATORY AND METABOLIC DETERMINANTS OF CORONARY CALCIFICATION IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE//New Day in Medicine 5(91)2026 137-143 https://newdayworldmedicine.com/en/new_day_medicine/5-91-2026

List of References

1. World Health Organization Cardiology. Cardiovascular diseases (CVDs). Geneva: World Health Organization; 2024.
2. Greenland P, Blaha MJ, Budoff MJ, et al. Coronary calcium score and cardiovascular risk assessment. J Am Coll Cardiol. 2021;78(2):157-172.
3. Budoff MJ, Young R, Lopez VA, et al. Progression of coronary calcium and cardiovascular outcomes. JACC Cardiovasc Imaging. 2020;13(2):345-356.
4. Hutcheson JD, Maldonado N, Aikawa E. Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability. Curr Opin Lipidol. 2021;32(5):327-333. DOI: 10.1097/MOL.0000000000000770.
5. Hecht HS, Blaha MJ, Berman DS, et al. Coronary artery calcium scoring: current status and future directions. JACC Cardiovasc Imaging. 2022;15(3):579-596.
6. Ridker PM. From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection. Circ Res. 2021;128(9):145-156.
7. Libby P, Loscalzo J, Ridker PM, et al. Inflammation, immunity, and infection in atherothrombosis. J Am Coll Cardiol. 2022;79(10):1010-1028.
8. Reaven GM. Insulin resistance and cardiovascular disease. Diabetes Care. 2020;43(9):203-212.
9. Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2021;101(4):1565-1620.
10. Neeland IJ, Poirier P, Després JP. Cardiovascular and metabolic heterogeneity of obesity. Circulation. 2021;143(5):476-493.
11. Tajani A, Sadeghi M, Omidkhoda N, et al. The association between C-reactive protein and coronary artery calcification: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2024;24:204. DOI: 10.1186/s12872-024-03866-2.
12. Shahraki N, Samadi S, Arasteh O, et al. Cardiac troponins and coronary artery calcium score: a systematic review. BMC Cardiovasc Disord. 2024;24:96. DOI: 10.1186/s12872-024-03695-3.
13. De Luca G, Verdoia M, Cassetti E, et al. Coronary inflammation: identification, clinical impact and possible therapeutical solutions. Int J Cardiol. 2026;134229. DOI: 10.1016/j.ijcard.2025.134229.

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