29 -5 (91) 2026 - Khalilova F.A., Gadaev A.G. - THE RELATIONSHIP BETWEEN UROMODULIN AND CARDIAC-RENAL HEMODYNAMIC PARAMETERS IN CARDIORENAL SYNDROME

THE RELATIONSHIP BETWEEN UROMODULIN AND CARDIAC-RENAL HEMODYNAMIC PARAMETERS IN CARDIORENAL SYNDROME

Khalilova F.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Gadaev A.G. - Tashkent State Medical University

Gadaeva N.A. - Tashkent State Medical University

Boboev A.T. - Republican Specialized Scientific and Practical Medical Hematology Center

Resume

The article presents a comprehensive assessment of the relationship between uromodulin levels and cardiac-renal hemodynamic parameters in cardiorenal syndrome (CRS) developed against the background of chronic heart failure (CHF). The study included 240 participants: Group 1 — with CRS (n=100), Group 2 — CHF without CRS (n=100), Group 3 — control (n=40). Echocardiography (PHILIPS Affiniti 70) and renal artery Doppler allowed assessment of parameters (LVEF, ESD, EDD, E/A, Vps, Ved, RI, PI). In the CRS group, uromodulin was 58.4±1.7 ng/ml, LVEF 38.4±0.6%, RI 0.76±0.01. Correlations were established between uromodulin and LVEF (r=+0.63), E/A (r=+0.70), RI (r=−0.67), and PI (r=−0.70). The results confirm uromodulin as a comprehensive marker of cardiorenal interaction. 4 diagrams and 2 tables are presented.

Keywords: cardiorenal syndrome, uromodulin, cardiac hemodynamics, renal hemodynamics, echocardiography, Doppler ultrasonography, resistance index, correlation analysis.

First page

170

Last page

176

For citation:Khalilova F.A., Gadaev A.G., Gadaeva N.A., Boboev A.T. - THE RELATIONSHIP BETWEEN UROMODULIN AND CARDIAC-RENAL HEMODYNAMIC PARAMETERS IN CARDIORENAL SYNDROME//New Day in Medicine 5(91)2026 170-176 https://newdayworldmedicine.com/en/new_day_medicine/5-91-2026

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