35 -5 (91) 2026 - Khalilova F.A., Boboev A.T. - THE INFLUENCE OF UMOD GENE rs4293393 A/G POLYMORPHISM ON THE COURSE OF CHRONIC HEART FAILURE AND CARDIORENAL SYNDROME

THE INFLUENCE OF UMOD GENE rs4293393 A/G POLYMORPHISM ON THE COURSE OF CHRONIC HEART FAILURE AND CARDIORENAL SYNDROME

Khalilova F.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Boboev A.T. - Republican Specialized Scientific and Practical Medical Hematology Center

Gadayev A.G. - Tashkent State Medical University

Turakulov R.I. - Tashkent State Medical University

Resume

The article presents a comprehensive assessment of the clinical, biochemical, and prognostic significance of the UMOD gene rs4293393 A/G polymorphism in cardiorenal syndrome (CRS) developed against the background of chronic heart failure (CHF). The study included 240 participants: Group 1 — with CRS (n=100), Group 2 — control (n=40). In the CRS group, the pathological G/G genotype was identified in 37% (n=37), A/G in 11% (n=11), A/A in 52% (n=52). In the control group, G/G was 7.5%. The G/G genotype increased CRS risk 6.75-fold (OR=6.754; CI 2.949–15.469; p<0.001). G/G carriers showed uromodulin 44.2±1.2 ng/ml (A/A: 69.7±1.3), cystatin-C 1.76±0.01 mg/l (A/A: 1.49±0.016), clinical status score 7.9 (A/A: 5.8), 6-minute walk 225.8 m (A/A: 310 m). 4 diagrams and 2 tables are presented.

Keywords: UMOD gene, rs4293393 polymorphism, cardiorenal syndrome, genetic risk factors, Hardy-Weinberg equilibrium, odds ratio, quality of life, pharmacogenetics.

First page

199

Last page

205

For citation:Khalilova F.A., Boboev A.T., Gadayev A.G., Turakulov R.I. - THE INFLUENCE OF UMOD GENE rs4293393 A/G POLYMORPHISM ON THE COURSE OF CHRONIC HEART FAILURE AND CARDIORENAL SYNDROME//New Day in Medicine 5(91)2026 199-205 https://newdayworldmedicine.com/en/new_day_medicine/5-91-2026

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