36 -5 (91) 2026 - Egamkulov U.K., Sharipova O.A. - THE ROLE OF PERSISTENT HERPES VIRUSES (HSV-1, HSV-2, CMV) AND GENETIC PREDICTORS OF SUSCEPTIBILITY IN THE PROGRESSION OF VALVULAR PATHOLOGY IN PATIENTS WITH RHEUMATIC HEART DISEASE

THE ROLE OF PERSISTENT HERPES VIRUSES (HSV-1, HSV-2, CMV) AND GENETIC PREDICTORS OF SUSCEPTIBILITY IN THE PROGRESSION OF VALVULAR PATHOLOGY IN PATIENTS WITH RHEUMATIC HEART DISEASE

Egamkulov U.K. - Samarkand State Medical University

Sharipova O.A. - Kimyo International University in Tashkent

Ergashev S.S. - Samarkand State Medical University

Resume

A retrospective analysis of 485 cardiac surgeries performed at the Samarkand Cardiology Center (2021–2025) was conducted. Herpesvirus DNA was detected in 33 of 50 patients (66%): HSV-1 monoinfection in 12 (24%), HSV-2 in 8 (16%), and CMV in 13 (26%). In the PCR-positive group, signs of active inflammation (lymphohistiocytic infiltration, mucoid stromal swelling, neoangiogenesis; p<0.05) were significantly more frequent, while in the PCR-negative group, chronic changes (hyalinosis, fibrinosis) with a minimal cellular response predominated. Among PCR-positive patients, 87.8% (29 of 33) underwent valve replacement (p<0.05), while in the PCR-negative group, valve replacement was performed in 47% (8 of 17), indirectly indicating more severe damage in virus-associated disease.

Keywords: herpes viruses, cardiac surgery interventions, valve replacement, PCR diagnostics, virus-associated process.

First page

206

Last page

208

For citation:Egamkulov U.K., Sharipova O.A., Ergashev S.S. - THE ROLE OF PERSISTENT HERPES VIRUSES (HSV-1, HSV-2, CMV) AND GENETIC PREDICTORS OF SUSCEPTIBILITY IN THE PROGRESSION OF VALVULAR PATHOLOGY IN PATIENTS WITH RHEUMATIC HEART DISEASE//New Day in Medicine 5(91)2026 206-208 https://newdayworldmedicine.com/en/new_day_medicine/5-91-2026

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