46 -5 (91) 2026 - Kurambayev Y.B., Niyazmetov M.A. - FEATURES OF THE IMPACT OF PESTICIDES ON HEALTH AND INDICATORS OF EXTERNAL RESPIRATORY FUNCTION AND HEMODYNAMICS IN THE EXPERIMENT

FEATURES OF THE IMPACT OF PESTICIDES ON HEALTH AND INDICATORS OF EXTERNAL RESPIRATORY FUNCTION AND HEMODYNAMICS IN THE EXPERIMENT

Kurambayev Y.B. - Urgen Technological University RANCH, Faculty of Medical Sciences Khorezm region

Niyazmetov M.A. - Urgen Technological University RANCH, Faculty of Medical Sciences Khorezm region

Yuddashev J.I. - Urgen Technological University RANCH, Faculty of Medical Sciences Khorezm region

Yusupov S.K. - Urgen Technological University RANCH, Faculty of Medical Sciences Khorezm region

Nasirov T.K. - Urgen Technological University RANCH, Faculty of Medical Sciences Khorezm region

Resume

Objects of experimental and ecological-epidemiological research: Indicators of general morbidity in cotton-growing regions (experimental) and livestock farming regions (control) among the population of the Republic of Uzbekistan, methodology, non-breed cats of both sexes, weighing 2.2–4.5 kg. Objective of the research: The aim of this study is a comprehensive investigation of the general morbidity rate and indicators of external respiratory function and hemodynamics during acute oral poisoning of animals (FOP group) with a large dose of formathion (42.6 mg/kg). Research methods: Methods include a selective comprehensive study of the general morbidity rate, physiological, electrophysiological, biochemical, and statistical approaches. Results obtained: For the first time, a comprehensive experimental-clinical study was conducted on laboratory animals (cats) with experimentally modeled acute poisoning by formathion from the FOP group. The study of general morbidity indicators in areas with intensive pesticide use in cotton-growing regions (experimental) and livestock farming regions (control) among the population of the Republic of Uzbekistan revealed the development of tissue hypoxia. This condition appears to be the cause of the frequent spread of respiratory infections and allergic diseases in cotton-growing regions compared to livestock farming regions, which differ in the degree of territorial pesticide loads.

Keywords: pesticides, acute poisoning by formathion from the FOP group, external respiratory function, hemodynamics, Tiffeneau index, gas exchange.

First page

271

Last page

279

For citation:Kurambayev Y.B., Niyazmetov M.A., Yuddashev J.I., Yusupov S.K., Nasirov T.K. - FEATURES OF THE IMPACT OF PESTICIDES ON HEALTH AND INDICATORS OF EXTERNAL RESPIRATORY FUNCTION AND HEMODYNAMICS IN THE EXPERIMENT//New Day in Medicine 5(91)2026 271-279 https://newdayworldmedicine.com/en/new_day_medicine/5-91-2026

List of References

1. Агаджанян Н.А. Экология и здоровье человека. М.: Медицина; 1996. 200 с.
2. Abusuev SA, Khachirov DG. Remote of the usage of pesticides and the morbidity of diabetes mellitus in rural areas. Problems of Endocrinology. 1996;42(5):12-14.
3. Байда Л.К. Загрязнение окружающей среды пестицидами и здоровье детей, проживающих в районах их интенсивного применения. В: Проблемы гигиены и экологии пестицидов: тезисы докладов 6-й Всесоюзной конференции. Киев: ВНИИГИНТОКС; 1981. Т. 2. С. 217-219.
4. Голиков С.Н., Розенгарт В.И. Холинэстеразы и антихолинэстеразные вещества. Ленинград: Медицина; 1964. 382 с.
5. Каган Ю.С. Токсикология фосфорорганических пестицидов. Киев; 1977-1981.
6. Kurambaev YB. Features of health of children living in the cotton-growing regions of Uzbekistan. Bulletins of the Social Research Institute of Hygiene, Economics and Healthcare Management. Moscow. 1995;2:3-8.
7. Лужников Е.А. Клиническая токсикология. Москва: Медицина; 1982-1989.
8. Мациевский Д.Д. Исследования гемодинамики датчиком-паток давления. Бюллетень экспериментальной биологии и медицины. 1984;97(3):377-379.
9. Сидаренко Г.И. Отравление ядохимикатами. Москва; 1981. 210 с.
10. Ubaidullaeva KM. Clinical-functional features of chronic obstructive pulmonary disease in patients with organic chlorine pesticides in blood. The Problems of Tuberculosis and Lung Diseases. 2006;9:21-33.
11. Murphy RS, Hutz FW. Environmental Health Perspectives. 1983;48:81-86.
12. Курамбаев Я.К., Каримова З.Х. Особенности механизма развития и течения пневмонии при воздействии на организм пестицидов. Тиббиётда янги кун. 2022;9(47):479-486.

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