54 -5 (91) 2026 - N.R. Nigmatova, А.N. Akbarov - MORPHOLOGICAL CHARACTERISTICS OF THE PROCESS OF REGENERATION OF BONE TISSUE DEFECT IN RABBITES USING BG-1D IN EXPERIMENT

MORPHOLOGICAL CHARACTERISTICS OF THE PROCESS OF REGENERATION OF BONE TISSUE DEFECT IN RABBITES USING BG-1D IN EXPERIMENT

N.R. Nigmatova - Tashkent State Medical University

А.N. Akbarov - Tashkent State Medical University

Resume

The article presents the results of an experimental morphological study on the regeneration of artificially created bone tissue defects in rabbits using the biologically active osteosubstituting material BG-1D based on biologically active glass. The relevance of the work is determined by the need to develop osteoplastic materials possessing high biocompatibility, the ability to fully fill bone defects, ease of administration, and stimulating effects on osteogenesis processes. Two groups of animals were used in the experiment: in the experimental group, the defect was filled with BG-1D, while in the control group, the defect was left without plastic material. Observations were conducted dynamically after 1, 2, and 3 months, followed by macro- and microscopic examination of the bone tissue. Histological specimens were stained with hematoxylin and eozine and examined under a LEITZ BIOMED light microscope. It was established that in the experimental group, after 1 month, signs of partial fusion of the composite material with bone beams and the presence of spongy bone tissue around the defect zone were noted. The obtained data indicate that the use of BG-1D contributes to a more intensive and early course of reparative osteogenesis compared to independent bone tissue regeneration.

Keywords: biologically active glass, BG-1D, bone regeneration, osteogenesis, bone defect, osteoplastic material, biocompatibility, morphological study, rabbit experiment, maxillofacial surgery

First page

316

Last page

319

For citation:N.R. Nigmatova, А.N. Akbarov - MORPHOLOGICAL CHARACTERISTICS OF THE PROCESS OF REGENERATION OF BONE TISSUE DEFECT IN RABBITES USING BG-1D IN EXPERIMENT//New Day in Medicine 5(91)2026 316-319 https://newdayworldmedicine.com/en/new_day_medicine/5-91-2026

List of References

1. Tulyaganov DU, Agathopoulos S, Dimitriadis K, Fernandes HR, Gabrieli R, Baino F. The story, properties and applications of bioactive glass “1d”: from concept to early clinical trials. Inorganics. 2024;12(8):224. doi:10.3390/inorganics12080224.
2. Tulyaganov DU, Akbarov A, Ziyadullaeva N, Khabilov B, Baino F. Injectable bioactive glass-based pastes for potential use in bone tissue repair. Biomedical Glasses. 2020;6(1):23-33. doi:10.1515/bglass-2020-0003.
3. Акбаров АН, Зиядуллаева НС, Хабилов БН. Использование костнопластических материалов для восстановления полостных дефектов челюстно-лицевых костей. Stomatologiya. 2019;(2):67-72.
4. Акбаров А, Хабилов Б, Умарова Б. Хроническая токсичность синтетического остеопластического материала «Oss. Uz». Scientific Collection “InterConf+”. 2023;(32):489-498.
5. Зиядуллаева НС, Акбаров АН, Тулаганов ДУ. Новые возможности в регенеративной стоматологии с применением скаффолдов (обзор литературы). Re-health Journal. 2021;1(9):160-167.
6. Avzal A, Bekzod K, Nigora Z, Nigman K, Dilshat T. Morphological characteristics of the process of regeneration of rabbit bone tissue defect using paste-like composite in the experiment. International Journal of Pharmaceutical Research. 2020;12(2):725-728. doi:10.31838/ijpr/2020.12.02.0104.

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