75 -2 (88) 2026 - Malikov A.N., Isanbayeva L.M. - CONTEMPORARY TRENDS IN THE DIAGNOSIS OF PROGRESSION OF PROLIFERATIVE DISEASES OF THE REPRODUCTIVE ORGANS AND OPPORTUNITIES FOR THEIR CORRECTION

CONTEMPORARY TRENDS IN THE DIAGNOSIS OF PROGRESSION OF PROLIFERATIVE DISEASES OF THE REPRODUCTIVE ORGANS AND OPPORTUNITIES FOR THEIR CORRECTION

Malikov A.N. - Republican Specialized Scientific and Practical Medical Center for Maternal and Child Health

Isanbayeva L.M. - Republican Specialized Scientific and Practical Medical Center for Maternal and Child Health

Doniyorova Ch.T. - Republican Specialized Scientific and Practical Medical Center for Maternal and Child Health

Resume

This study is aimed at evaluating the clinical and diagnostic significance of estrogen metabolite imbalance in women with adenomyosis and impaired reproductive function. The study included 32 reproductive-aged women with adenomyosis and infertility, as well as 30 healthy women who formed the control group. All participants underwent comprehensive examination, including clinical, ultrasound, biochemical, and endoscopic methods. Urinary concentrations of estrogen metabolites (2-hydroxyestrone, 4-hydroxyestrone, and 16α-hydroxyestrone) were determined using the ESTRAMET 2/16 ELISA test system. The results demonstrated a significant increase in proliferative estrogen metabolites, particularly 16α-hydroxyestrone and 4-hydroxyestrone, along with a decrease in the protective metabolite 2-hydroxyestrone in patients with adenomyosis (p<0.01). A reduced 2-hydroxyestrone/16α-hydroxyestrone ratio was associated with clinical signs of hormonal imbalance, anovulation, and infertility. These findings confirm the high diagnostic value of estrogen metabolite profiling and highlight its potential for developing personalized hormonal correction strategies in women with adenomyosis.

Keywords: Adenomyosis, endometriosis, estrogen metabolites, 2-hydroxyestrone, 4-hydroxyestrone, 16α-hydroxyestrone, estrogen metabolism, proliferative processes, hormonal imbalance, infertility, reproductive dysfunction.

First page

378

Last page

380

For citation:Malikov A.N., Isanbayeva L.M., Doniyorova Ch.T. - CONTEMPORARY TRENDS IN THE DIAGNOSIS OF PROGRESSION OF PROLIFERATIVE DISEASES OF THE REPRODUCTIVE ORGANS AND OPPORTUNITIES FOR THEIR CORRECTION//New Day in Medicine 2(88)2026 378-380 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

1. Johnson N.P., Hummelshoj L. Consensus on current management of endometriosis. Human Reprod 2013;28(6):1552-1568.
2. Ашрафян Л.А., Киселев В.И., Муйжнек Е.Л. Патогенетическая профилактика рака репродуктивных органов. М: Молодая гвардия 2009.
3. Адамян Л.В., Кулаков В.И., Андреева Е.Н. Эндометриозы. М: Медицина 2006.
4. Fedele L., Bianchi S., Zanconato G., Bettoni G., Gotsch F. Long term follow-up after conservative surgery for rectovaginal endometriosis. Am J Obstet Gynecol 2004;190:1020-1024.
5. Wheeler J.M. Epidemiology and prevalence of endometriosis. Infertil Reprod Med Clin North Am 1992;3:545-549.
6. Kennedy S.H., Mardon H.J., Barlow D.H. Familial endometriosis. J Ass Reprod Genet 1995;72:32-34.
7. Pascual M. Role of color Doppler ultrasonography in the diagnosis of endometriotic cyst. J Ultrasound Med 2000;19:695-699.
8. Lemos N., Arbo E., Scalco R. et al. Fertil Steril 2008;89:1064-1068.
9. Курило Л.Ф., Михалева Л.М., Адамян Л.В. и др. Количественный анализ состава фолликулов яичника при эндометриозе. Пробл репрод 2006;12(3):34-36.
10. Exacoustous C. et al. Лапароскопическое удаление эндометриомы: измерение остаточного объема яичника с помощью ультразвука. AJOG 2004;191:68-72

    file

    download