96 -2 (88) 2026 - Radjabov A.B., Sharipova Sh.O. - ANALYSIS OF MORPHOFUNCTIONAL CHANGES IN THE ESOPHAGUS OBSERVED UNDER THE INFLUENCE OF NICOTINE, ALCOHOL, AND NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)

ANALYSIS OF MORPHOFUNCTIONAL CHANGES IN THE ESOPHAGUS OBSERVED UNDER THE INFLUENCE OF NICOTINE, ALCOHOL, AND NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)

Radjabov A.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Sharipova Sh.O. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Today, the use of several types of nonsteroidal anti-inflammatory drugs (NSAIDs), as well as nicotine and alcohol consumption, is increasingly widespread worldwide and has become an urgent problem, with a noticeable shift toward younger age groups. Research evidence indicates that these factors exert a significant impact on the esophageal wall. The esophagus is a well-vascularized tubular organ that connects the pharynx to the stomach; various harmful environmental factors not only have a direct toxic effect on the esophageal mucosa but also adversely affect its motility and peristalsis. This article discusses and reviews the scientific studies conducted worldwide to date that focus on the effects of NSAIDs, nicotine, and alcohol on the esophagus.

Keywords: nicotine, alcohol, esophagus, nonsteroidal anti-inflammatory drugs (NSAIDs) , morphology

First page

502

Last page

505

For citation:Radjabov A.B., Sharipova Sh.O. - ANALYSIS OF MORPHOFUNCTIONAL CHANGES IN THE ESOPHAGUS OBSERVED UNDER THE INFLUENCE OF NICOTINE, ALCOHOL, AND NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)//New Day in Medicine 2(88)2026 502-505 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

1. Caputo F, Guarino M, Casabianca A, Lungaro L, Costanzini A, Caio G, Zoli G, De Giorgio R. Effects of ethanol on the digestive system: a narrative review. J Transl Gastroenterol. 2024;000(000):000–000. doi:10.14218/JTG.2024.00028
2. Bujanda L. The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol. 2000;95(12):3374–3382. doi:10.1111/j.1572-0241.2000.03347.x. PMID:1115186
3. Haber PS, Kortt NC. Alcohol use disorder and the gut. Addiction. 2021;116(3):658–667. doi:10.1111/add.15147. PMID:32511812
4. Grad S, Abenavoli L, Dumitrascu DL. The effect of alcohol on gastrointestinal motility. Rev Recent Clin Trials. 2016;11(3):191–195. doi:10.2174/1574887111666160815103251. PMID:27527893
5. Roman-Campos D, Cruz JS. Current aspects of thiamine deficiency on heart function. Life Sci. 2014;98(1):1–5. doi:10.1016/j.lfs.2013.12.029. PMID:24398040
6. Scherübl H. Alcohol use and gastrointestinal cancer risk. Visc Med. 2020;36(3):175–181. doi:10.1159/000507232. PMID:32775347
7. Uhlenhopp DJ, Then EO, Sunkara T, Gaduputi V. Epidemiology of esophageal cancer: update in global trends, etiology and risk factors. Clin J Gastroenterol. 2020;13(6):1010–1021. doi:10.1007/s12328-020-01237-x. PMID:32965635
8. Salaspuro M. Key role of local acetaldehyde in upper GI tract carcinogenesis. Best Pract Res Clin Gastroenterol. 2017;31(5):491–499. doi:10.1016/j.bpg.2017.09.016. PMID:29195668
9. Lipka S, Kumar A, Richter JE. Impact of diagnostic delay and other risk factors on eosinophilic esophagitis phenotype and esophageal diameter. J Clin Gastroenterol. 2016;50(2):134–140.
10. Corley DA, Kerlikowske K, Verma R, Buffler P. Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis. Gastroenterology. 2003;124(1):47–56.

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